ArticleStem cells (Dayton, Ohio)2009
The role of PTIP in maintaining embryonic stem cell pluripotency.
Article in Stem cells (Dayton, Ohio), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Melatonin Improves Bovine Embryo Production and Quality via Antioxidant, Metabolic, and Epigenetic Pathways.Antioxidants (Basel, Switzerland) · 2025Article
- Article
- Epigenetic modification in diabetic kidney disease.Frontiers in endocrinology · 2023Review
- Identification of Pax protein inhibitors that suppress target gene expression and cancer cell proliferation.Cell chemical biology · 2022Article
- Bivalent Regulation and Related Mechanisms of H3K4/27/9me3 in Stem Cells.Stem cell reviews and reports · 2022Review
- PTIP Inhibits Cell Invasion in Esophageal Squamous Cell CarcinomaFrontiers in oncology · 2021Article
- PTIP promotes recurrence and metastasis of hepatocellular carcinoma by regulating epithelial-mesenchymal transition.Oncotarget · 2017Article
- A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.Genes & development · 2016Article
- Evidence for intermediate mesoderm and kidney progenitor cell specification by Pax2 and PTIP dependent mechanisms.Developmental biology · 2015Article
- The Groucho-associated phosphatase PPM1B displaces Pax transactivation domain interacting protein (PTIP) to switch the transcription factor Pax2 from a transcriptional activator to a repressor.The Journal of biological chemistry · 2015Article
- Review
- Arrested spermatogenesis and evidence for DNA damage in PTIP mutant testes.Developmental biology · 2013Article
- Epigenetic mechanisms of Groucho/Grg/TLE mediated transcriptional repression.Molecular cell · 2012Article
- Patterning and early cell lineage decisions in the developing kidney: the role of Pax genes.Pediatric nephrology (Berlin, Germany) · 2011Review
- Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes.The Journal of clinical investigation · 2011Article
- Role of PTIP in class switch recombination and long-range chromatin interactions at the immunoglobulin heavy chain locus.Molecular and cellular biology · 2011Article
- Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotype.PLoS genetics · 2010Article
- Histone demethylase LSD1 regulates adipogenesis.The Journal of biological chemistry · 2010Article
- Induction of pluripotent stem cells from human third molar mesenchymal stromal cells.The Journal of biological chemistry · 2010Article
- The specification and maintenance of renal cell types by epigenetic factors.Organogenesis · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Pax transactivation domain-interacting protein (PTIP) is a ubiquitously expressed, nuclear protein that is part of a histone H3K4 methyltransferase complex and is essential for embryonic development. Methylation of H3K4 is an epigenetic mark found on many critical developmental regulatory genes in embryonic stem (ES) cells and, together with H3K27 methylation, constitutes a bivalent epigenetic signature. To address the function of PTIP in ES cells, we generated ES cell lines from a floxed ptip allele and deleted PTIP function with Cre recombinase. The ptip(-/-) ES cell lines exhibited a high degree of spontaneous differentiation to trophectoderm and a loss of pluripotency. Reduced levels of Oct4 expression and H3K4 methylation were observed. Upon differentiation, ptip(-/-) embryoid bodies showed reduced levels of marker gene expression for all three primary germ layers. These results suggest that the maintenance of H3K4 methylation is essential and requires PTIP function during the in vitro propagation of pluripotent ES cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.