ArticleStem cells (Dayton, Ohio)2009
Stem cell transplant into preimplantation embryo yields myocardial infarction-resistant adult phenotype.
Article in Stem cells (Dayton, Ohio), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Optimizing stem cells for cardiac repair: Current status and new frontiers in regenerative cardiology.World journal of stem cells · 2017Review
- Regenerative Therapy Prevents Heart Failure Progression in Dyssynchronous Nonischemic Narrow QRS Cardiomyopathy.Journal of the American Heart Association · 2015Article
- Inhibition of DNA topoisomerase II selectively reduces the threat of tumorigenicity following induced pluripotent stem cell-based myocardial therapy.Stem cells and development · 2014Article
- Therapeutic effects of induced pluripotent stem cells in chimeric mice with β-thalassemia.Haematologica · 2014Article
- Mechanical dyssynchrony precedes QRS widening in ATP-sensitive K⁺ channel-deficient dilated cardiomyopathy.Journal of the American Heart Association · 2013Article
- In vivo reprogramming in inflammatory bowel disease.Gene therapy · 2013Review
- Induced pluripotent stem cell intervention rescues ventricular wall motion disparity, achieving biological cardiac resynchronization post-infarction.The Journal of physiology · 2013Article
- Mechanisms for progenitor cell-mediated repair for ischemic heart injury.Current stem cell research & therapy · 2012Review
- Regional and systemic hemodynamic responses following the creation of a murine arteriovenous fistula.American journal of physiology. Renal physiology · 2011Article
- Injection of wild type embryonic stem cells into Mst1 transgenic blastocysts prevents adult-onset cardiomyopathy.Stem cell reviews and reports · 2011Article
- Guided cardiopoiesis enhances therapeutic benefit of bone marrow human mesenchymal stem cells in chronic myocardial infarction.Journal of the American College of Cardiology · 2010Article
- ATP-sensitive K(+) channel-deficient dilated cardiomyopathy proteome remodeled by embryonic stem cell therapy.Stem cells (Dayton, Ohio) · 2010Article
- Stem cells in the infarcted heart.Journal of cardiovascular translational research · 2010Review
- Rescue of developmental defects by blastocyst stem cell injection: towards elucidation of neomorphic corrective pathways.Journal of cardiovascular translational research · 2010Article
- Induced pluripotent stem cells: advances to applications.Stem cells and cloning : advances and applications · 2010Article
- Blastocyst injection of embryonic stem cells: a simple approach to unveil mechanisms of corrections in mouse models of human disease.Stem cell reviews and reports · 2009Review
- Targeted disruption of K(ATP) channels aggravates cardiac toxicity in cocaine abuse.Clinical and translational science · 2009Article
- iPS programmed without c-MYC yield proficient cardiogenesis for functional heart chimerism.Circulation research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Stem cells are an emerging strategy for treatment of myocardial infarction, limited however to postinjury intervention. Preventive stem cell-based therapy to augment stress tolerance has yet to be considered for lifelong protection. Here, pluripotent stem cells were microsurgically introduced at the blastocyst stage of murine embryo development to ensure stochastic integration and sustained organ contribution. Engineered chimera displayed excess in body weight due to increased fat deposits, but were otherwise devoid of obesity-related morbidity. Remarkably, and in sharp contrast to susceptible nonchimeric offspring, chimera was resistant to myocardial infarction induced by permanent coronary occlusion. Infarcted nonchimeric adult hearts demonstrated progressive deterioration in ejection fraction, while age-matched 12-14-months-old chimera recovered from equivalent ischemic insult to regain within one-month preocclusion contractile performance. Electrical remodeling and ventricular enlargement with fibrosis, prominent in failing nonchimera, were averted in the chimeric cohort characterized by an increased stem cell load in adipose tissue and upregulated markers of biogenesis Ki67, c-Kit, and stem cell antigen-1 in the myocardium. Favorable outcome in infarcted chimera translated into an overall benefit in workload capacity and survival. Thus, prenatal stem cell transplant yields a cardioprotective phenotype in adulthood, expanding cell-based indications beyond traditional postinjury applications to include pre-emptive therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.