ArticleAngiogenesis2009
Influence of the oxygen microenvironment on the proangiogenic potential of human endothelial colony forming cells.
Article in Angiogenesis, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Chondroitin Sulfate-Based MPDA@MnOPolymers · 2026Article
- Article
- miR-130a activates the VEGFR2/STAT3/HIF1α axis to potentiate the vasoregenerative capacity of endothelial colony-forming cells in hypoxia.Molecular therapy. Nucleic acids · 2021Article
- Restoring vasculogenic potential of endothelial cells from diabetic patients through spheroid formation.Cellular and molecular bioengineering · 2018Article
- Hypoxia Impairs Initial Outgrowth of Endothelial Colony Forming Cells and Reduces Their Proliferative and Sprouting Potential.Frontiers in medicine · 2018Article
- Article
- Engineering fibrin hydrogels to promote the wound healing potential of mesenchymal stem cell spheroids.Acta biomaterialia · 2017Article
- Multifactorial Experimental Design to Optimize the Anti-Inflammatory and Proangiogenic Potential of Mesenchymal Stem Cell Spheroids.Stem cells (Dayton, Ohio) · 2017Article
- Polydimethylsiloxane-polycarbonate Microfluidic Devices for Cell Migration Studies Under Perpendicular Chemical and Oxygen Gradients.Journal of visualized experiments : JoVE · 2017Article
- Hypoxia-induced responses by endothelial colony-forming cells are modulated by placental growth factor.Stem cell research & therapy · 2016Article
- Hydrogel biophysical properties instruct coculture-mediated osteogenic potential.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Atorvastatin protects endothelial colony‑forming cells against H2O2‑induced oxidative damage by regulating the expression of annexin A2.Molecular medicine reports · 2015Article
- Engineered Fibrin Gels for Parallel Stimulation of Mesenchymal Stem Cell Proangiogenic and Osteogenic Potential.Annals of biomedical engineering · 2015Article
- A novel microfluidic platform for studying mammalian cell chemotaxis in different oxygen environments under zero-flow conditions.Biomicrofluidics · 2015Article
- Hypoxia augments outgrowth endothelial cell (OEC) sprouting and directed migration in response to sphingosine-1-phosphate (S1P).PloS one · 2015Article
- Enhanced trophic factor secretion by mesenchymal stem/stromal cells with Glycine-Histidine-Lysine (GHK)-modified alginate hydrogels.Acta biomaterialia · 2014Article
- Lysophosphatidic acid protects human mesenchymal stromal cells from differentiation-dependent vulnerability to apoptosis.Tissue engineering. Part A · 2014Article
- Collagen-polymer guidance of vessel network formation and stabilization by endothelial colony forming cells in vitro.Macromolecular bioscience · 2013Article
- Bioceramic-mediated trophic factor secretion by mesenchymal stem cells enhances in vitro endothelial cell persistence and in vivo angiogenesis.Tissue engineering. Part A · 2012Article
- Differentiation-dependent secretion of proangiogenic factors by mesenchymal stem cells.PloS one · 2012Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Therapeutic angiogenesis is a promising strategy to promote the formation of new or collateral vessels for tissue regeneration and repair. Since changes in tissue oxygen concentrations are known to stimulate numerous cell functions, these studies have focused on the oxygen microenvironment and its role on the angiogenic potential of endothelial cells. We analyzed the proangiogenic potential of human endothelial colony-forming cells (hECFCs), a highly proliferative population of circulating endothelial progenitor cells, and compared outcomes to human dermal microvascular cells (HMVECs) under oxygen tensions ranging from 1% to 21% O2, representative of ischemic or healthy tissues and standard culture conditions. Compared to HMVECs, hECFCs (1) exhibited significantly greater proliferation in both ischemic conditions and ambient air; (2) demonstrated increased migration compared to HMVECs when exposed to chemotactic gradients in reduced oxygen; and (3) exhibited comparable or superior proangiogenic potential in reduced oxygen conditions when assessed using a vessel-forming assay. These data demonstrate that the angiogenic potential of both endothelial populations is influenced by the local oxygen microenvironment. However, hECFCs exhibit a robust angiogenic potential in oxygen conditions representative of physiologic, ischemic, or ambient air conditions, and these findings suggest that hECFCs may be a superior cell source for use in cell-based approaches for the neovascularization of ischemic or engineered tissues.
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Registered trials
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