ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2010
Interaction between cyanobacterial copper chaperone Atx1 and zinc homeostasis.
Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Distinct function of Chlamydomonas CTRA-CTR transporters in Cu assimilation and intracellular mobilization.Metallomics : integrated biometal science · 2024Article
- Zn deficiency disrupts Cu and S homeostasis in Chlamydomonas resulting in over accumulation of Cu and Cysteine.Metallomics : integrated biometal science · 2023Article
- Article
- Current knowledge and recent advances in understanding metabolism of the model cyanobacterium Synechocystis sp. PCC 6803.Bioscience reports · 2020Review
- Bacterial sensors define intracellular free energies for correct enzyme metalation.Nature chemical biology · 2019Article
- AztD, a Periplasmic Zinc Metallochaperone to an ATP-binding Cassette (ABC) Transporter System in Paracoccus denitrificans.The Journal of biological chemistry · 2015Article
- Generating a Metal-responsive Transcriptional Regulator to Test What Confers Metal Sensing in Cells.The Journal of biological chemistry · 2015Article
- T versus D in the MTCXXC motif of copper transport proteins plays a role in directional metal transport.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2014Article
- A chemical potentiator of copper-accumulation used to investigate the iron-regulons of Saccharomyces cerevisiae.Molecular microbiology · 2014Article
- Metal specificity of cyanobacterial nickel-responsive repressor InrS: cells maintain zinc and copper below the detection threshold for InrS.Molecular microbiology · 2014Article
- Recent developments in copper and zinc homeostasis in bacterial pathogens.Current opinion in chemical biology · 2014Review
- Predicting copper-, iron-, and zinc-binding proteins in pathogenic species of the Paracoccidioides genus.Frontiers in microbiology · 2014Article
- Investigating the role of zinc and copper binding motifs of trafficking sites in the cyanobacterium Synechocystis PCC 6803.Biochemistry · 2013Article
- Crosstalk between Cu(I) and Zn(II) homeostasis via Atx1 and cognate domains.Chemical communications (Cambridge, England) · 2013Article
- Cytosolic Ni(II) sensor in cyanobacterium: nickel detection follows nickel affinity across four families of metal sensors.The Journal of biological chemistry · 2012Article
- Cyanobacterial metallochaperone inhibits deleterious side reactions of copper.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Thermodynamics of copper and zinc distribution in the cyanobacterium Synechocystis PCC 6803.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Metalloregulatory proteins: metal selectivity and allosteric switching.Biophysical chemistry · 2011Review
- The CRR1 nutritional copper sensor in Chlamydomonas contains two distinct metal-responsive domains.The Plant cell · 2010Article
- NMR structural analysis of the soluble domain of ZiaA-ATPase and the basis of selective interactions with copper metallochaperone Atx1.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2010Article
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4 authors at 1 institution in 1 country.
Funding
Abstract
Cyanobacterial Atx1 is a copper chaperone which interacts with two copper-transporting ATPases to assist copper supply to plastocyanin and cytochrome oxidase. ZiaA is a Zn(2+)-exporting ATPase and ziaA expression is regulated by ZiaR. Here we show that gene expression from the ziaA operator promoter, monitored using reverse transcriptase PCR and lacZ fusions, is elevated in Deltaatx1 mutants. Although Cu(+) tightly binds recombinant ZiaR in vitro, Cu(+) is less effective at dissociating ZiaR-DNA complexes than Zn(2+) and crucially ziaA expression responds to Zn(2+) but not copper in both wild-type and Deltaatx1 cells. Consistent with enhanced expression of ZiaA, Deltaatx1 cells have slightly elevated Zn(2+) resistance. Recombinant Zn(2+)-Atx1 is recovered from Zn(2+)-supplemented Escherichia coli and even after copper supplementation substantial amounts of Zn(2+)-Atx1 are isolated. Taken together, these data suggest that Zn(2+)-Atx1 can form in vivo.
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