ArticleJournal of cancer research and clinical oncology2009
Overweight is associated with improved cancer-specific survival in patients with organ-confined renal cell carcinoma.
Article in Journal of cancer research and clinical oncology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- The Association Between Body Mass Index and the Prognosis and Postoperative Complications of Hepatocellular Carcinoma: A Meta-Analysis.Medicine · 2015Pooled it
- ERK/MAPK Signalling Pathway Regulates MMP2 through ETS1 in Renal Clear Cell Carcinoma.Current molecular medicine · 2024Article
- Body mass index as an independent prognostic factor in glioblastoma.Cancer causes & control : CCC · 2021Article
- The number of metabolic features as a significant prognostic factor in patients with metastatic renal cell carcinoma.Scientific reports · 2020Article
- Impact of overweightness and critical weight loss on overall survival in patients with hepatocellular carcinoma initially treated with chemoembolization.Gastroenterology report · 2020Article
- miR-4521-FAM129A axial regulation on ccRCC progression through TIMP-1/MMP2/MMP9 and MDM2/p53/Bcl2/Bax pathways.Cell death discovery · 2019Article
- Association of body mass index with mortality and postoperative survival in renal cell cancer patients, a meta-analysis.Oncotarget · 2018Article
- The value of complementing administrative data with abstracted information on smoking and obesity: A study in kidney cancer.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2017Article
- Prognostic value of alpha-methyl CoA racemase (AMACR) expression in renal cell carcinoma.World journal of urology · 2013Article
- Influence of body mass index, smoking, and blood pressure on survival of patients with surgically-treated, low stage renal cell carcinoma: a 14-year retrospective cohort study.Journal of Korean medical science · 2013Article
- Predicting factors for death from other causes in patients with localized renal cell carcinoma.Korean journal of urology · 2012Article
- [Overweight is an advantageous prognostic marker in patients with clear cell kidney cancer].Der Urologe. Ausg. A · 2011Article
- An elevated body mass index does not reduce survival after esophagectomy for cancer.Annals of surgical oncology · 2011Article
- Does obesity influence the prognosis of metastatic renal cell carcinoma in patients treated with vascular endothelial growth factor-targeted therapy?The oncologist · 2011Article
- Article
- Influence of body mass index on complications and oncologic outcomes following hepatectomy for malignancy.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2010Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesOverweight/obesity is known to increase the risk of developing renal cell carcinoma (RCC). However, data on the prognostic impact of overweight in RCC is still conflicting. We assessed whether different body mass index (BMI) levels at the time of surgery had an effect on the long-term prognosis of RCC patients.
methodsWe evaluated 771 patients, with complete information about their BMI, who had undergone renal surgery for RCC between 1990 and 2005 at the authors' institution; the mean follow-up was 5.48 years.
resultsUnderweight, normal weight, pre-obesity, and obesity were diagnosed in 4 (0.5%), 239 (31%), 356 (46.2%), and 172 (22.3%) RCC patients, respectively. Overweight (BMI >25) was significantly associated with younger age (P = 0.004) and positive nodal status (P = 0.04) but not with tumor stage, grade, visceral metastasis, gender, histological subtype, or tumor-related symptoms. Overweight patients had a significantly lower risk of cancer-related death; their median 5-year tumor-specific survival rate was 80% as opposed to 72% for patients with a BMI below 25 (P = 0.003). Interestingly, subgroup analysis revealed that the positive association between overweight and survival was even more pronounced in organ-confined (P < 0.001) RCC, but no correlation was observed in advanced disease (P = 0.23).
conclusionWe were able to identify overweight as an independent prognostic marker of improved tumor-specific survival in patients with organ-confined RCC. Basic research is required to resolve the dilemma of why, if a higher BMI predisposes to RCC, it concurrently prolongs survival after patients have undergone (partial) nephrectomy.
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