Evidence map›Paper›PMID 19543765›Full record

ReviewOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2009

Global vitamin D status and determinants of hypovitaminosis D.

A Mithal, D A Wahl, J-P Bonjour, P Burckhardt, B Dawson-Hughes, J A Eisman, G El-Hajj Fuleihan, R G Josse, P Lips, J Morales-Torres and 1 more

Erratum issued 3 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to 3 registered trials, which are not on this map. Cited by 659 papers, 16 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
659citing papers in PubMed, 16 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01991054 phase4completednot on this mapstarted 2013, after this paper: background citation

A Prospective, Double Blind, Randomized, Phase 4, Clinical Trial of The Effects of Vitamin D Supplementation on Patients With Type 2 Diabetes and Vitamin D Deficiency

TypeinterventionalSponsorHaEmek Medical Center, IsraelRan2013 to 2018Enrolled45ConditionsDiabetes Mellitus, Vitamin D DeficiencyArmsvitamin D3
NCT02434380 phase3completednot on this mapstarted 2015, after this paper: background citation

Effect of Vitamin D Replacement on Maternal and Neonatal Outcomes: a Randomized Controlled Trial in Pregnant Women With Hypovitaminosis D

TypeinterventionalSponsorAmerican University of Beirut Medical CenterRan2015 to 2018Enrolled330ConditionsHypovitaminosis D, Pregnancy Complications, Infant, Newborn, DiseasesArmsEuro D
NCT05863949 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

STOP Vertigo: Supplementation of Vitamin D for Termination of Recurrences From Benign Paroxysmal Positional Vertigo

TypeinterventionalSponsorOttawa Hospital Research InstituteRan2025 to 2026Enrolled860ConditionsBPPV, Benign Paroxysmal Positional Vertigo, Vertigo, Vertigo, PeripheralArmsvitamin D +/- calcium, Placebo
3 · Its place in the literature

Who cites it

659 citing papers in PubMed, 16 syntheses or guidelines pooled it.

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  11. Deficiency and Insufficiency of Vitamin D in Women of Childbearing Age: A Systematic Review and Meta-analysis.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2022
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  13. Association of serum 25(OH)Vit-D levels with risk of pediatric fractures: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021
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599 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

11 authors.

A MithalIndraprastha Apollo Hospitals, Sarita Vihar, Delhi-Mathura Road, 110044 New Delhi, India. ambrish.mithal@rediffmail.com
D A Wahl
J-P Bonjour
P Burckhardt
B Dawson-Hughes
J A Eisman
G El-Hajj Fuleihan
R G Josse
P Lips
J Morales-Torres
IOF Committee of Scientific Advisors (CSA) Nutrition Working Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledThis review describes the vitamin D status in different regions of the world with the objective of understanding the scope of hypovitaminosis D and the factors related to its prevalence that may contribute to the pathogenesis of osteoporosis and fragility fractures.

introductionVitamin D status has been linked to the pathogenesis of hip fractures as well as other skeletal and non-skeletal disorders. The purpose of this review is to provide a global perspective of vitamin D status across different regions of the world and to identify the common and significant determinants of hypovitaminosis D.

methodsSix regions of the world were reviewed-Asia, Europe, Middle East and Africa, Latin America, North America, and Oceania-through a survey of published literature.

resultsThe definition of vitamin D insufficiency and deficiency, as well as assay methodology for 25-hydroxyvitamin D or 25(OH)D, vary between studies. However, serum 25(OH)D levels below 75 nmol/L are prevalent in every region studied whilst levels below 25 nmol/L are most common in regions such as South Asia and the Middle East. Older age, female sex, higher latitude, winter season, darker skin pigmentation, less sunlight exposure, dietary habits, and absence of vitamin D fortification are the main factors that are significantly associated with lower 25(OH)D levels.

conclusionReports from across the world indicate that hypovitaminosis D is widespread and is re-emerging as a major health problem globally.

Indexed as

Global HealthAdolescentAdultAgedAge FactorsChildChild, PreschoolCross-Cultural ComparisonFemaleGenetic Predisposition to DiseaseHumansInfantInfant, NewbornMaleMiddle AgedPrevalenceVitamin D

Identifiers

PMID19543765

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.