ArticleDose-response : a publication of International Hormesis Society2009
Radiation-stimulated epigenetic reprogramming of adaptive-response genes in the lung: an evolutionary gift for mounting adaptive protection against lung cancer.
Article in Dose-response : a publication of International Hormesis Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- The radiation adaptive response and priming dose influence: the quantification of the Raper-Yonezawa effect and its three-parameter model for postradiation DNA lesions and mutations.Radiation and environmental biophysics · 2022Article
- Differential molecular response in mice and human thymocytes exposed to a combined-dose radiation regime.Scientific reports · 2022Article
- Molecular Characterization and Identification ofPlants (Basel, Switzerland) · 2020Article
- Early-life adversity and long-term neurobehavioral outcomes: epigenome as a bridge?Human genomics · 2017Review
- Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications.Frontiers of medicine · 2015Review
- Radiation-hormesis phenotypes, the related mechanisms and implications for disease prevention and therapy.Journal of cell communication and signaling · 2014Article
- First generation stochastic gene episilencing (step1) model and applications to in vitro carcinogen exposure.Dose-response : a publication of International Hormesis Society · 2013Article
- Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives.Current pharmaceutical design · 2013Review
- The new radiobiology: returning to our roots.Dose-response : a publication of International Hormesis Society · 2012Article
- Low-dose gamma-radiation inhibits benzo[a]pyrene-induced lung adenoma development in a/j mice.Dose-response : a publication of International Hormesis Society · 2012Article
- Small γ-Ray Doses Prevent Rather than Increase Lung Tumors in Mice.Dose-response : a publication of International Hormesis Society · 2012Article
- Radiation and cancer risk: a continuing challenge for epidemiologists.Environmental health : a global access science source · 2011Review
- Modeling DNA double-strand break repair kinetics as an epiregulated cell-community-wide (epicellcom) response to radiation stress.Dose-response : a publication of International Hormesis Society · 2011Article
- Residential radon appears to prevent lung cancer.Dose-response : a publication of International Hormesis Society · 2011Article
- Epidemiological Evidence for Possible Radiation Hormesis from Radon Exposure: A Case-Control Study Conducted in Worcester, MA.Dose-response : a publication of International Hormesis Society · 2010Article
- Stochastic threshold microdose model for cell killing by insoluble metallic nanomaterial particles.Dose-response : a publication of International Hormesis Society · 2010Article
- Radiation hormesis: historical perspective and implications for low-dose cancer risk assessment.Dose-response : a publication of International Hormesis Society · 2010Article
- Hormesis, adaptive epigenetic reorganization, and implications for human health and longevity.Dose-response : a publication of International Hormesis Society · 2010Article
- The healthy worker effect and nuclear industry workers.Dose-response : a publication of International Hormesis Society · 2010Article
- Modeling Cell Reactions to Ionizing Radiation: From a Lesion to a Cancer.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Humans are continuously exposed to low-level ionizing radiation from natural sources. However, harsher radiation environments persisted during our planet's early years and mammals survived via an evolutionary gift--a system of radiation-induced natural protective measures (adaptive protection). This system includes antioxidants, DNA repair, apoptosis of severely damaged cells, epigenetically regulated apoptosis (epiapoptosis) pathways that selectively remove precancerous and other aberrant cells, and immunity against cancer. We propose a novel model in which the protective system is regulated at least in part via radiation-stress-stimulated epigenetic reprogramming (epireprogramming) of adaptive-response genes. High-dose radiation can promote epigenetically silencing of adaptive-response genes (episilencing), for example via promoter-associated DNA and/or histone methylation and/or histone deacetylation. Evidence is provided for low linear-energy-transfer (LET) radiation-activated natural protection (ANP) against high-LET alpha-radiation-induced lung cancer in plutonium-239 exposed rats and radon-progeny-exposed humans. Using a revised hormetic relative risk model for cancer induction that accounts for both epigenetic activation (epiactivation) and episilencing of genes, we demonstrate that, on average, >80% of alpha-radiation-induced rat lung cancers were prevented by chronic, low-rate gamma-ray ANP. Interestingly, lifetime exposure to residential radon at the Environmental Protection Agency's action level of 4 pCi L(-1) appears to be associated with on average a > 60% reduction in lung cancer cases, rather than an increase. We have used underlined italics to indicate newly introduced terminology.
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