ArticleNature neuroscience2009
Cellular and systems mechanisms of memory strength as a constraint on auditory fear reconsolidation.
Article in Nature neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
128 citing papers in PubMed, 3 syntheses or guidelines pooled it, 314 citations in OpenAlex.
- Effects of ketamine on fear memory extinction: a review of preclinical literature.Frontiers in neuroscience · 2025Pooled it
- Modulation of naturalistic maladaptive memories using behavioural and pharmacological reconsolidation-interfering strategies: a systematic review and meta-analysis of clinical and 'sub-clinical' studies.Psychopharmacology · 2018Pooled it
- Harnessing reconsolidation to weaken fear and appetitive memories: A meta-analysis of post-retrieval extinction effects.Psychological bulletin · 2016Pooled it
- Stimulation of the noradrenergic system during memory formation impairs extinction learning but not the disruption of reconsolidation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2012Trial
- Neurotransmitters in memory destabilization: An integrative perspective framed by prediction error and novelty.Cognitive, affective & behavioral neuroscience · 2026Review
- The clinically relevant MEK inhibitor mirdametinib combined with D-cycloserine and prediction error disrupts fear memory in PTSD models.Translational psychiatry · 2024Article
- Male rats emit aversive 44-kHz ultrasonic vocalizations during prolonged Pavlovian fear conditioning.eLife · 2024Article
- Dual-step pharmacological intervention for traumatic-like memories: implications from D-cycloserine and cannabidiol or clonidine in male and female rats.Psychopharmacology · 2024Article
- Context and Time Regulate Fear Memory Consolidation and Reconsolidation in the Basolateral Amygdala Complex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Memory persistence: from fundamental mechanisms to translational opportunities.Translational psychiatry · 2024Review
- Article
- Muscarinic receptor activation overrides boundary conditions on memory updating in a calcium/calmodulin-dependent manner.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Appraising reconsolidation theory and its empirical validation.Psychonomic bulletin & review · 2023Review
- Refinement of the stress-enhanced fear learning model of post-traumatic stress disorder: a behavioral and molecular analysis.Lab animal · 2022Article
- Evidence on the impairing effects of Ayahuasca on fear memory reconsolidation.Psychopharmacology · 2022Article
- Testing the memory reconsolidation hypothesis in a fear extinction paradigm: The effects of ecological and arbitrary stimuli.Learning & behavior · 2022Article
- Prelimbic proBDNF Facilitates Retrieval-Dependent Fear Memory Destabilization by Regulation of Synaptic and Neural Functions in Juvenile Rats.Molecular neurobiology · 2022Article
- Sleep enhances reconsolidation-based strengthening of visuospatial memories.Scientific reports · 2022Article
- Demarcating the boundary conditions of memory reconsolidation: An unsuccessful replication.Scientific reports · 2022Article
- Procedures between training and reactivation influence the destabilization of instrumental sucrose memory.Frontiers in behavioral neuroscience · 2022Article
68 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Memory reconsolidation has been demonstrated in various tasks and species, suggesting it is a fundamental process. However, there are experimental parameters that can inhibit reconsolidation from occurring (boundary conditions). These conditions and their mechanisms remain poorly defined. Here, we characterize the ability of strong training to inhibit reconsolidation at the behavioral, systems and molecular levels. We demonstrate that strong memories in rats initially are resistant to reconsolidation, but after sufficient time will undergo reconsolidation, suggesting that boundary conditions can be transient. At the systems level, we show that the hippocampus is necessary for inhibiting reconsolidation in the amygdala. At the molecular level, we demonstrate that NR2B NMDA-receptor subunits which are critical for the induction of reconsolidation of auditory memories in the amygdala, are downregulated only under conditions when strong memories do not undergo reconsolidation. This suggests that one molecular mechanism for mediating boundary conditions is through downregulation of reconsolidation induction mechanisms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.