ArticleJournal of endocrinological investigation2009
Effectiveness of retinoic acid treatment for redifferentiation of thyroid cancer in relation to recovery of radioiodine uptake.
Article in Journal of endocrinological investigation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- From bench to bedside: the evolving role of iodine in thyroid cancer management.Nature reviews. Endocrinology · 2026Review
- Therapeutic Potential of Sodium Selenite Application for Promoting Radioactive Iodine Avidity in Papillary Thyroid Cancer.Bioinorganic chemistry and applications · 2026Article
- Redifferentiation therapy in unresectable or metastatic radioactive iodine refractory thyroid cancer: an International Thyroid Oncology Group statement.The lancet. Diabetes & endocrinology · 2025Review
- Towards updated understanding of brain metastasis.American journal of cancer research · 2022Review
- Thyroid Carcinoma: Phenotypic Features, Underlying Biology and Potential Relevance for Targeting Therapy.International journal of molecular sciences · 2021Review
- Review
- Multi-omics Signatures and Translational Potential to Improve Thyroid Cancer Patient Outcome.Cancers · 2019Review
- Sodium Iodide Symporter (NIS) in the Management of Patients with Thyroid Carcinoma.Nuclear medicine and molecular imaging · 2018Article
- Novel targeted therapies and immunotherapy for advanced thyroid cancers.Molecular cancer · 2018Review
- Differentiation therapy revisited.Nature reviews. Cancer · 2018Review
- Simvastatin Inhibits Cell Proliferation and Migration in Human Anaplastic Thyroid Cancer.International journal of molecular sciences · 2017Article
- Redifferentiation of Radioiodine Refractory Differentiated Thyroid Cancer for Reapplication of I-131 Therapy.Frontiers in endocrinology · 2017Review
- PDGFRα Regulates Follicular Cell Differentiation Driving Treatment Resistance and Disease Recurrence in Papillary Thyroid Cancer.EBioMedicine · 2016Article
- Radioiodine therapy in differentiated thyroid cancer: the first targeted therapy in oncology.Endocrinology and metabolism (Seoul, Korea) · 2014Review
- mTOR Inhibition promotes TTF1-dependent redifferentiation and restores iodine uptake in thyroid carcinoma cell lines.The Journal of clinical endocrinology and metabolism · 2014Article
- Long-term prognosis of differentiated thyroid cancer with lung metastasis in Korea and its prognostic factors.Thyroid : official journal of the American Thyroid Association · 2014Article
- Retinoid acid receptor expression is helpful to distinguish between adenoma and well-differentiated carcinoma in the thyroid.Virchows Archiv : an international journal of pathology · 2013Article
- Alternative medical treatment for radioiodine-refractory thyroid cancers.Nuclear medicine and molecular imaging · 2011Review
- Combined therapy with 131I and retinoic acid in Korean patients with radioiodine-refractory papillary thyroid cancer.European journal of nuclear medicine and molecular imaging · 2011Article
- AUF1 and HuR: possible implications of mRNA stability in thyroid function and disorders.Thyroid research · 2011Article
Corrections and comments
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRetinoic acid (RA) treatment has been used for redifferentiation of metastatic thyroid neoplasia that have lost radioiodine (131I) uptake with heterogeneous results.
aimRetrospective analysis of the recovery rate of 131I uptake after RA treatment in patients from 11 Spanish hospitals.
methodsTwenty-seven patients (14 men, 13 women) with papillary [21], follicular [4], and oncocytic [2] thyroid cancer initially treated with total thyroidectomy plus 131I, and with 131I negative metastatic disease, were given 13-cis RA (0.66-1.5 mg/kg for 5-12 weeks) followed by a therapeutic 131I dose (3700-7400 MBq); 3 months later thyroglobulin levels and computed tomography imaging were performed.
resultsIn 9 out 27 cases (33%) (8 papillary, 1 follicular) optimal positive 131I scan was observed after RA treatment; in the remaining 18, 10 had a suboptimal uptake (7 papillary, 2 follicular, 1 oncocytic) and in the rest there was no 131I uptake recovery (6 papillary, 1 follicular, 1 oncocytic). In 17 positive responses to RA (either optimal or suboptimal) in which image follow-up was available, decrease or stabilization of metastatic growth was observed in 7, while tumor mass increased at short term in the remaining 10. No major side effects were detected.
conclusionQuite a high rate of 131I uptake recovery after RA treatment may be obtained in advanced differentiated thyroid cancer, but the potential modification of the natural course of the disease is uncertain. A better biological characterization of these tumors allowing the identification of potential responders to RA may improve the outcome of RA coadjuvant therapy.
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