ArticleJournal of immunology (Baltimore, Md. : 1950)2009
The influence of IgE-enhancing and IgE-suppressive gammadelta T cells changes with exposure to inhaled ovalbumin.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 53 citations in OpenAlex.
- Effect of immunostimulation with bacterial lysate on the clinical course of allergic rhinitis and the level of γδT, iNKT and cytotoxic T cells in children sensitized to grass pollen allergens: A randomized controlled trial.Frontiers in immunology · 2023Trial
- Targeted replacement of human γδ TCR in mice enhances antigen-specific B cell immunity.Frontiers in immunology · 2026Article
- Partial Compensation of IL-17 Production by Vγ1 T Cells in the Absence of Vγ4 and Vγ6 T Cells.European journal of immunology · 2025Article
- Review
- Innate and Adaptive Immune Responses to Clinical Hyaluronic Acid Fillers.Journal of cosmetic dermatology · 2025Article
- Decoding innate lymphoid cells and innate-like lymphocytes in asthma: pathways to mechanisms and therapies.Journal of biomedical science · 2025Review
- γδ T Cells and Allergic Diseases.Clinical reviews in allergy & immunology · 2023Review
- The function of γδ T cells in humoral immune responses.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023Review
- Immunomodulatory effect of marine lipids on food allergy.Frontiers in nutrition · 2023Review
- γδ T Lymphocytes in Asthma: a Complicated Picture.Archivum immunologiae et therapiae experimentalis · 2021Review
- New Insights into Asthma Inflammation: Focus on iNKT, MAIT, and γδT Cells.Clinical reviews in allergy & immunology · 2020Review
- Innate-like Lymphocytes and Innate Lymphoid Cells in Asthma.Clinical reviews in allergy & immunology · 2020Review
- γδ T cells in rheumatic diseases: from fundamental mechanisms to autoimmunity.Seminars in immunopathology · 2019Review
- Article
- γδ T cells control humoral immune response by inducing T follicular helper cell differentiation.Nature communications · 2018Article
- γδ T cells provide the early source of IFN-γ to aggravate lesions in spinal cord injury.The Journal of experimental medicine · 2018Article
- Lung-resident γδ T cells and their roles in lung diseases.Immunology · 2017Review
- Vγ1⁺ γδT Cells Are Correlated With Increasing Expression of Eosinophil Cationic Protein and Metalloproteinase-7 in Chronic Rhinosinusitis With Nasal Polyps Inducing the Formation of Edema.Allergy, asthma & immunology research · 2017Article
- A Special Connection between γδ T Cells and Natural Antibodies?Archivum immunologiae et therapiae experimentalis · 2016Review
- γδ T Cells Shape Preimmune Peripheral B Cell Populations.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
It has been reported that the IgE response to allergens is influenced by gammadelta T cells. Intrigued by a study showing that airway challenge of mice with OVA induces in the spleen the development of gammadelta T cells that suppress the primary IgE response to i.p.-injected OVA-alum, we investigated the gammadelta T cells involved. We found that the induced IgE suppressors are contained within the Vgamma4(+) subset of gammadelta T cells of the spleen, that they express Vdelta5 and CD8, and that they depend on IFN-gamma for their function. However, we also found that normal nonchallenged mice harbor IgE-enhancing gammadelta T cells, which are contained within the larger Vgamma1(+) subset of the spleen. In cell transfer experiments, airway challenge of the donors was required to induce the IgE suppressors among the Vgamma4(+) cells. Moreover, this challenge simultaneously turned off the IgE enhancers among the Vgamma1(+) cells. Thus, airway allergen challenge differentially affects two distinct subsets of gammadelta T cells with nonoverlapping functional potentials, and the outcome is IgE suppression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.