ArticleJournal of immunology (Baltimore, Md. : 1950)2009
Peripheral induction of tolerance by retinal antigen expression.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
- Infection control in the brain and the eye.Acta ophthalmologica · 2026Review
- Tolerance Induction in Relation to the Eye.Frontiers in immunology · 2018Review
- Retinal antigen-specific regulatory T cells protect against spontaneous and induced autoimmunity and require local dendritic cells.Journal of neuroinflammation · 2014Article
- Ex-vivo tolerogenic F4/80⁺ antigen-presenting cells (APC) induce efferent CD8⁺ regulatory T cell-dependent suppression of experimental autoimmune uveitis.Clinical and experimental immunology · 2014Article
- Lymphopenia-induced proliferation in aire-deficient mice helps to explain their autoimmunity and differences from human patients.Frontiers in immunology · 2014Review
- Local "on-demand" generation and function of antigen-specific Foxp3+ regulatory T cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Local activation of dendritic cells alters the pathogenesis of autoimmune disease in the retina.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Regulation of CD8(+) T Cell Responses to Retinal Antigen by Local FoxP3(+) Regulatory T Cells.Frontiers in immunology · 2012Article
- Good news-bad news: the Yin and Yang of immune privilege in the eye.Frontiers in immunology · 2012Article
- Cutting-edge issues in autoimmune uveitis.Clinical reviews in allergy & immunology · 2011Review
- Dendritic cell control of tolerogenic responses.Immunological reviews · 2011Review
- A look at autoimmunity and inflammation in the eye.The Journal of clinical investigation · 2010Review
- The Induction of Circulating, ACAID-Inducing Monocytes Requires CCR2/CCL2-Dependent Migration of Circulating F4/80(+) Cells into the Anterior Chamber.Ophthalmology and eye diseases · 2010Article
- Generation of Regulatory T Cells to Antigen Expressed in the Retina.Current immunology reviewsArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The contribution of peripheral expression of tissue-specific CNS Ags to the generation of tolerance is uncertain. To study this question, we examined mice transgenic (Tg) for expression of beta-galactosidase (beta gal) on the retinal photoreceptor cell arrestin promoter, in conjunction with TCR Tg mice producing CD4(+) T cells specific for beta gal (beta galTCR). Several strategies were used to test the hypothesis that betagal expressed in the retina supported thymus-independent tolerance and regulatory T cell development. Retinal expression generated an immunoregulatory response that depressed development of immune responses to beta gal following systemic immunization with beta gal. This regulation was transferable to naive mice by CD3(+)4(+)25(+) T cells from naive retinal beta gal(+) donors. Experiments that removed the beta gal(+) retina by enucleation showed that subsequent development of a regulatory response was lost. Adoptive transfer of CD25(-) beta galTCR T cells into retinal beta gal Tg mice on the Rag(-/-) background led to regulatory activity that limited lymphopenia-induced proliferation of beta galTCR T cells in mice with retinal expression of beta gal and inhibited the ear-swelling assay for delayed type hypersensitivity. These results show that retinal expression of very small amounts of a tissue-specific Ag can generate tolerance that includes regulatory T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.