ArticleJournal of immunology (Baltimore, Md. : 1950)2009
Successful treatment of bacterial infection hinders development of acquired immunity.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Lack of homologous protection against Campylobacter jejuni CG8421 in a human challenge model.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Trial
- Antibiotic Treatment of Staphylococcus aureus Infection Inhibits the Development of Protective Immunity.Antimicrobial agents and chemotherapy · 2022Article
- Dual Immunization with SseB/Flagellin Provides Enhanced Protection againstJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- Collateral Damage: Detrimental Effect of Antibiotics on the Development of Protective Immune Memory.mBio · 2016Review
- Haemophilus parasuis: infection, immunity and enrofloxacin.Veterinary research · 2015Review
- Direct visualization of endogenous Salmonella-specific B cells reveals a marked delay in clonal expansion and germinal center development.European journal of immunology · 2015Article
- Contaminated water delivery as a simple and effective method of experimental Salmonella infection.Future microbiology · 2015Article
- Immunity to intestinal pathogens: lessons learned from Salmonella.Immunological reviews · 2014Review
- A capsule conjugate vaccine approach to prevent diarrheal disease caused by Campylobacter jejuni.Human vaccines & immunotherapeutics · 2014Review
- Cutting edge: B cells are essential for protective immunity against Salmonella independent of antibody secretion.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Drug treatment of malaria infections can reduce levels of protection transferred to offspring via maternal immunity.Proceedings. Biological sciences · 2012Article
- Extensive in vivo resilience of persistent Salmonella.PloS one · 2012Article
- Temporal expression of bacterial proteins instructs host CD4 T cell expansion and Th17 development.PLoS pathogens · 2012Article
- Development of protective immunity to Salmonella, a mucosal pathogen with a systemic agenda.Mucosal immunology · 2011Review
- Dissemination of persistent intestinal bacteria via the mesenteric lymph nodes causes typhoid relapse.Infection and immunity · 2011Article
- Early eradication of persistent Salmonella infection primes antibody-mediated protective immunity to recurrent infection.Microbes and infection · 2011Article
- Article
- Innate immune activation during Salmonella infection initiates extramedullary erythropoiesis and splenomegaly.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- B7-H1 (programmed cell death ligand 1) is required for the development of multifunctional Th1 cells and immunity to primary, but not secondary, Salmonella infection.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Comments to metallothionein as an anti-inflammatory mediator.Mediators of inflammation · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Antibiotics are routinely used to control bacterial infection, but the acquisition of acquired immunity following successful treatment has rarely been examined. We developed a model that allows visualization of acquired immunity during and following antibiotic treatment of typhoid. Pathogen-specific humoral and cellular immune responses were activated rapidly in antibiotic-treated mice, but were not sustained after successful antibiotic treatment and did not confer protection to secondary infection. In marked contrast, pathogen-specific Th1 and Ab responses matured over several weeks following immunization with a live vaccine strain. The deficiency in protective immunity following antibiotic treatment could be overcome by administering flagellin during antibiotic therapy. Thus, development of protective immunity is hindered by rapid therapeutic elimination of bacteria, but can be overcome by providing additional inflammatory and/or antigenic stimuli.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.