ArticleThe Plant cell2009
The plastidic bile acid transporter 5 is required for the biosynthesis of methionine-derived glucosinolates in Arabidopsis thaliana.
Article in The Plant cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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65 citing papers in PubMed, 130 citations in OpenAlex.
- ATML1-GIR1-TPL/TPR transcriptional repression module controls glucosinolates and giant cells inbioRxiv : the preprint server for biology · 2026Article
- Glucosinolates inInternational journal of molecular sciences · 2026Review
- Genome-wide characterization of soybean bile acid: sodium symporter genes reveals a positive role of GmBASS2-2 in salt stress response.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Deciphering the heterogeneous glucosinolates composition in leaves and seeds: strategies for developing Brassica napus genotypes with low seed glucosinolates content but high leaf glucosinolates content.Molecular horticulture · 2025Article
- Effect of sodium selenite on the synthesis of glucosinolates and antioxidant capacity in Chinese cabbage (Physiology and molecular biology of plants : an international journal of functional plant biology · 2024Article
- Improved pokeweed genome assembly and early gene expression changes in response to jasmonic acid.BMC plant biology · 2024Article
- Genome-Wide Identification and Expression Analysis ofCurrent issues in molecular biology · 2024Article
- Evolution and comparative transcriptome analysis of glucosinolate pathway genes inFrontiers in plant science · 2024Article
- Article
- Identification of new potential downstream transcriptional targets of the strigolactone pathway including glucosinolate biosynthesis.Plant direct · 2023Article
- Genome-Wide Association Study of Glucosinolate Metabolites (mGWAS) inPlants (Basel, Switzerland) · 2023Article
- Genetic Improvement ofPlants (Basel, Switzerland) · 2023Review
- Transcriptomic and epigenomic analyses revealed that polycomb repressive complex 2 regulates not only developmental but also stress responsive metabolism inFrontiers in plant science · 2023Article
- Genome-Wide Association Study of Phenylalanine Derived Glucosinolates inPlants (Basel, Switzerland) · 2022Article
- A Comparative Transcriptome and Metabolome Combined Analysis Reveals the Key Genes and Their Regulatory Model Responsible for Glucoraphasatin Accumulation in Radish Fleshy Taproots.International journal of molecular sciences · 2022Article
- Identification of Potential Genes Encoding Protein Transporters inLife (Basel, Switzerland) · 2022Article
- Structural Studies of Aliphatic Glucosinolate Chain-Elongation Enzymes.Antioxidants (Basel, Switzerland) · 2021Review
- Influence of Genotype on High Glucosinolate Synthesis Lines ofInternational journal of molecular sciences · 2021Article
- Genome-wide identification of the BASS gene family in four Gossypium species and functional characterization of GhBASSs against salt stress.Scientific reports · 2021Article
- Dissecting the Role of SAL1 in Metabolizing the Stress Signaling Molecule 3'-Phosphoadenosine 5'-Phosphate in Different Cell Compartments.Frontiers in molecular biosciences · 2021Article
5 more citing papers are in PubMed but not listed here.
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6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Aliphatic glucosinolate biosynthesis is highly compartmentalized, requiring import of 2-keto acids or amino acids into chloroplasts for side chain elongation and export of the resulting compounds into the cytosol for conversion into glucosinolate. Aliphatic glucosinolate biosynthesis in Arabidopsis thaliana is regulated by three R2R3-MYB transcription factors, the major player being High Aliphatic Glucosinolate 1 (HAG1/MYB28). Here, we show that BAT5, which belongs to the putative bile acid transporter family, is the only member of this family that is transactivated by HAG1/MYB28, HAG2/MYB76, and HAG3/MYB29. Furthermore, two isopropylmalate isomerases genes, IPMI1 and IPMI2, and the isopropylmalate dehydrogenase gene, IPMDH1, were identified as targets of HAG1/MYB28 and the corresponding proteins localized to plastids, suggesting a role in plastidic chain elongation reactions. The BAT proteins also localized to plastids; however, only mutants defective in BAT5 function contained strongly reduced levels of aliphatic glucosinolates. The bat5 mutant chemotype was rescued by induced overexpression of BAT5. Feeding experiments using 2-keto acids and amino acids of different chain length suggest that BAT5 is a plastidic transporter of (chain-elongated) 2-keto acids. Mechanical stimuli and methyl jasmonate transiently induced BAT5 expression in inflorescences and leaves. Thus, BAT5 was identified as the first transporter component of the aliphatic glucosinolate biosynthetic pathway.
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