ArticleJournal of bacteriology2009
CsrRS regulates group B Streptococcus virulence gene expression in response to environmental pH: a new perspective on vaccine development.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 88 citations in OpenAlex.
- Virulence and pathogenicity of group BVirulence · 2025Review
- Identification of glyoxalase A in group BInfection and immunity · 2025Article
- Group B streptococcal infections in pregnancy and early life.Clinical microbiology reviews · 2025Review
- Identification of Glyoxalase A in Group BbioRxiv : the preprint server for biology · 2024Article
- Prevalence and Antibiotic Resistance ofLife (Basel, Switzerland) · 2024Article
- Triple threat: how diabetes results in worsened bacterial infections.Infection and immunity · 2024Review
- Unveiling the regulatory network controlling natural transformation in lactococci.PLoS genetics · 2024Article
- Gestational diabetes augments group B Streptococcus infection by disrupting maternal immunity and the vaginal microbiota.Nature communications · 2024Article
- Vaginal microbial dynamics and pathogen colonization in a humanized microbiota mouse model.NPJ biofilms and microbiomes · 2023Article
- Group B Streptococcus and diabetes: Finding the sweet spot.PLoS pathogens · 2023Article
- Molecular Epidemiology of Group B Streptococcus Colonization in Egyptian Women.Microorganisms · 2022Article
- Alterations of the vaginal microbiome in healthy pregnant women positive for group B Streptococcus colonization during the third trimester.BMC microbiology · 2022Article
- The Role of Regulator Catabolite Control Protein A (CcpA) in Streptococcus agalactiae Physiology and Stress Response.Microbiology spectrum · 2022Article
- Manganese transport by Streptococcus sanguinis in acidic conditions and its impact on growth in vitro and in vivo.Molecular microbiology · 2022Article
- Immunogenic Proteins of Group B Streptococcus-Potential Antigens in Immunodiagnostic Assay for GBS Detection.Pathogens (Basel, Switzerland) · 2021Review
- Investigation of the polyamine biosynthetic and transport capability ofMicrobiology (Reading, England) · 2021Article
- The CovR regulatory network drives the evolution of Group B Streptococcus virulence.PLoS genetics · 2021Article
- Article
- Phenotypic changes in group B streptococci grown in the presence of the polyols, erythritol, sorbitol and mannitol.BMC microbiology · 2021Article
- Genome-Wide fitness analysis of group B Streptococcus in human amniotic fluid reveals a transcription factor that controls multiple virulence traits.PLoS pathogens · 2021Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
To identify factors involved in the response of group B streptococci (GBS) to environmental pH, we performed a comparative global gene expression analysis of GBS at acidic and neutral pHs. We found that the transcription of 317 genes was increased at pH 5.5 relative to that at pH 7.0, while 61 genes were downregulated. The global response to acid stress included the differential expression of genes involved in transport, metabolism, stress response, and virulence. Known vaccine candidates, such as BibA and pilus components, were also regulated by pH. We observed that many of the genes involved in the GBS response to pH are known to be controlled by the CsrRS two-component system. Comparison of the regulon of wild-type strain 2603 V/R with that of a csrRS deletion mutant strain revealed that the pH-dependent regulation of 90% of the downregulated genes and 59.3% of the up-regulated genes in strain 2603 V/R was CsrRS dependent and that many virulence factors were overexpressed at high pH. Beta-hemolysin regulation was abrogated by selective inactivation of csrS, suggesting the implication of the CsrS protein in pH sensing. These results imply that the translocation of GBS from the acidic milieu of the vagina to the neutral pH of the neonatal lung signals the up-regulation of GBS virulence factors and conversion from a colonizing to an invasive phenotype. In addition, the fact that increased exposure of BibA on the bacterial surface at pH 7.0 induced opsonophagocytic killing of GBS in immune serum highlights the importance of pH regulation in the protective efficacy of specific antibodies to surface-exposed GBS proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.