ArticleJournal of bacteriology2009
Optical mapping reveals a large genetic inversion between two methicillin-resistant Staphylococcus aureus strains.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- A subclade-associated genomic deletion encompassing vraDEH confers increased susceptibility to nisin A and bacitracin in Staphylococcus aureus CC121.Scientific reports · 2026Article
- Genomic characterization of a multidrug-resistantFrontiers in microbiology · 2025Article
- Complete Genome Sequence and Analysis of a ST573 Multidrug-Resistant Methicillin-ResistantPathogens (Basel, Switzerland) · 2023Article
- Clover: a clustering-oriented de novo assembler for Illumina sequences.BMC bioinformatics · 2020Article
- Noise reduction in single time frame optical DNA maps.PloS one · 2017Article
- SIMBA: a web tool for managing bacterial genome assembly generated by Ion PGM sequencing technology.BMC bioinformatics · 2016Article
- Whole-genome optical mapping reveals a mis-assembly between two rRNA operons of Corynebacterium pseudotuberculosis strain 1002.BMC genomics · 2016Article
- Article
- A fast and scalable kymograph alignment algorithm for nanochannel-based optical DNA mappings.PloS one · 2015Article
- Large chromosomal rearrangements during a long-term evolution experiment with Escherichia coli.mBio · 2014Article
- Beyond gel electrophoresis: microfluidic separations, fluorescence burst analysis, and DNA stretching.Chemical reviews · 2013Review
- Whole genome mapping and re-organization of the nuclear and mitochondrial genomes of Babesia microti isolates.PloS one · 2013Article
- Comparative Genomics Reveal That Host-Innate Immune Responses Influence the Clinical Prevalence of Legionella pneumophila Serogroups.PloS one · 2013Article
- Article
- Enhanced de novo assembly of high throughput pyrosequencing data using whole genome mapping.PloS one · 2013Article
- Genome sequence of Acinetobacter baumannii TYTH-1.Journal of bacteriology · 2012Article
- Comparative whole-genome mapping to determine Staphylococcus aureus genome size, virulence motifs, and clonality.Journal of clinical microbiology · 2012Article
- Genome sequence of a dominant, multidrug-resistant Acinetobacter baumannii strain, TCDC-AB0715.Journal of bacteriology · 2011Article
- Host specific diversity in Lactobacillus johnsonii as evidenced by a major chromosomal inversion and phage resistance mechanisms.PloS one · 2011Article
- Genomic analysis of Acinetobacter baumannii A118 by comparison of optical maps: identification of structures related to its susceptibility phenotype.Antimicrobial agents and chemotherapy · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Staphylococcus aureus is a highly versatile and evolving bacterium of great clinical importance. S. aureus can evolve by acquiring single nucleotide polymorphisms and mobile genetic elements and by recombination events. Identification and location of novel genomic elements in a bacterial genome are not straightforward, unless the whole genome is sequenced. Optical mapping is a new tool that creates a high-resolution, in situ ordered restriction map of a bacterial genome. These maps can be used to determine genomic organization and perform comparative genomics to identify genomic rearrangements, such as insertions, deletions, duplications, and inversions, compared to an in silico (virtual) restriction map of a known genome sequence. Using this technology, we report here the identification, approximate location, and characterization of a genetic inversion of approximately 500 kb of a DNA element between the NRS387 (USA800) and FPR3757 (USA300) strains. The presence of the inversion and location of its junction sites were confirmed by site-specific PCR and sequencing. At both the left and right junction sites in NRS387, an IS1181 element and a 73-bp sequence were identified as inverted repeats, which could explain the possible mechanism of the inversion event.
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