ArticleThe Journal of molecular diagnostics : JMD2009
CpG methylation analysis--current status of clinical assays and potential applications in molecular diagnostics: a report of the Association for Molecular Pathology.
Article in The Journal of molecular diagnostics : JMD, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Quantitative DNA melting analysis with hybridization probes (qDMA-HP) as a novel approach to assess MGMT promoter methylation in malignant glioma.Journal of neuro-oncology · 2026Article
- Nanopore sequencing-derived methylation biomarker prediction for methylation-specific PCR in patients with head and neck squamous cell carcinoma.Clinical epigenetics · 2025Article
- High-definition CpG methylation of novel genes in gastric carcinogenesis identified by next-generation sequencing.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Article
- Integration of molecular pathology, epidemiology and social science for global precision medicine.Expert review of molecular diagnostics · 2016Review
- Helicobacter pylori and microRNAs: Relation with innate immunity and progression of preneoplastic conditions.World journal of clinical oncology · 2015Review
- Clinical implications of the LINE-1 methylation levels in patients with gastrointestinal cancer.Surgery today · 2014Review
- Review
- Designing DNA interstrand lock for locus-specific methylation detection in a nanopore.Scientific reports · 2013Article
- Aberrant methylation of LINE-1, SLIT2, MAL and IGFBP7 in non-small cell lung cancer.Oncology reports · 2013Article
- Helicobacter, Inflammation, and Gastric Cancer.Current pathobiology reports · 2013Article
- Analysing and interpreting DNA methylation data.Nature reviews. Genetics · 2012Review
- DNA promoter methylation as a diagnostic and therapeutic biomarker in gallbladder cancer.Clinical epigenetics · 2012Article
- Article
- Precision of pyrosequencing assay to measure LINE-1 methylation in colon cancer, normal colonic mucosa, and peripheral blood cells.The Journal of molecular diagnostics : JMD · 2010Article
- Molecular detection of B-cell neoplasms by specific DNA methylation biomarkers.International journal of clinical and experimental pathology · 2010Article
- DNA hypomethylation in cancer cells.Epigenomics · 2009Review
- Immunohistochemical analysis of mismatch repair proteins in Iranian colorectal cancer patients at risk for lynch syndrome.Iranian journal of cancer preventionArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methylation of CpG islands in gene promoter regions is a major molecular mechanism of gene silencing and underlies both cancer development and progression. In molecular oncology, testing for the CpG methylation of tissue DNA has emerged as a clinically useful tool for tumor detection, outcome prediction, and treatment selection, as well as for assessing the efficacy of treatment with the use of demethylating agents and monitoring for tumor recurrence. In addition, because CpG methylation occurs early in pre-neoplastic tissues, methylation tests may be useful as markers of cancer risk in patients with either infectious or inflammatory conditions. The Methylation Working Group of the Clinical Practice Committee of the Association of Molecular Pathology has reviewed the current state of clinical testing in this area. We report here our summary of both the advantages and disadvantages of various methods, as well as the needs for standardization and reporting. We then conclude by summarizing the most promising areas for future clinical testing in cancer molecular diagnostics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.