Evidence map›Paper›PMID 19541916›Full record

Trial reportNeurorehabilitation and neural repair2009

Aerobic exercise improves cognition and motor function poststroke.

Barbara M Quaney, Lara A Boyd, Joan M McDowd, Laura H Zahner, Jianghua He, Matthew S Mayo, Richard F Macko

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neurorehabilitation and neural repair, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02553993 (Comparing the Cognitive Effects of Two Exergame Balance Training Systems and Traditional Weight Shifting Training in Patients With Chronic Stroke), which is not on this map. Cited by 113 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed, 20 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02553993 nacompletednot on this mapstarted 2013, after this paper: background citation

Comparing the Cognitive Effects of Two Exergame Balance Training Systems and Traditional Weight Shifting Training in Patients With Chronic Stroke

TypeinterventionalSponsorChang Gung Memorial HospitalRan2013 to 2015Enrolled43ConditionsStrokeArmsWii Fit(30 Mins), Tetrax biofeedback(30 Mins), Conventional weight-shifting(30 Mins)
3 · Its place in the literature

Who cites it

113 citing papers in PubMed, 20 syntheses or guidelines pooled it.

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  10. Cognitive rehabilitation for attention deficits following stroke.The Cochrane database of systematic reviews · 2019
    Pooled it
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  12. Circuit class therapy for improving mobility after stroke.The Cochrane database of systematic reviews · 2017
    Pooled it
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  14. Physical fitness training for stroke patients.The Cochrane database of systematic reviews · 2016
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  18. Cognitive rehabilitation for attention deficits following stroke.The Cochrane database of systematic reviews · 2013
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  19. Vascular cognitive impairment: disease mechanisms and therapeutic implications.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2011
    Pooled it
  20. Pooled it

53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Barbara M QuaneyDepartment of Neurology, Kansas University Medical Center, Kansas City, Kansas 66160, USA. bquaney@kumc.edu
Lara A Boyd
Joan M McDowd
Laura H Zahner
Jianghua He
Matthew S Mayo
Richard F Macko

Funding

Motor Performance and Cortical Changes in Chronic StrokeK01HD047148 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI QUANEY, BARBARA M · 2005 to 2009
$589k
NICHD NIH HHS K01 HD047148
6 · The paper itself

Abstract

backgroundCognitive deficits impede stroke recovery. Aerobic exercise (AEX) improves cognitive executive function (EF) processes in healthy individuals, although the learning benefits after stroke are unknown.

objectiveTo understand AEX-induced improvements in EF, motor learning, and mobility poststroke.

methodsFollowing cardiorespiratory testing, 38 chronic stroke survivors were randomized to 2 different groups that exercised 3 times a week (45-minute sessions) for 8 weeks. The AEX group (n = 19; 9 women; 10 men; 64.10 +/- 12.30 years) performed progressive resistive stationary bicycle training at 70% maximal heart rate, whereas the Stretching Exercise (SE) group (n = 19; 12 women; 7 men; 58.96 +/- 14.68 years) performed stretches at home. Between-group comparisons were performed on the change in performance at "Post" and "Retention" (8 weeks later) for neuropsychological and motor function measures.

resultsVO(2)max significantly improved at Post with AEX (P = .04). AEX also improved motor learning in the less-affected hand, with large effect sizes (Cohen's d calculation). Specifically, AEX significantly improved information processing speed on the serial reaction time task (SRTT; ie, "procedural motor learning") compared with the SE group at Post (P = .024), but not at Retention. Also, at Post (P = .038), AEX significantly improved predictive force accuracy for a precision grip task requiring attention and conditional motor learning of visual cues. Ambulation and sit-to-stand transfers were significantly faster in the AEX group at Post (P = .038), with balance control significantly improved at Retention (P = .041). EF measurements were not significantly different for the AEX group.

conclusionAEX improved mobility and selected cognitive domains related to motor learning, which enhances sensorimotor control after stroke.

Indexed as

ExerciseStroke RehabilitationBicyclingCognitionCognition DisordersDyskinesiasExecutive FunctionFemaleHandHumansLearningMaleMiddle AgedMotor SkillsMuscle Stretching ExercisesNeuropsychological Tests

Identifiers

PMID19541916
PMCPMC3024242

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.