Evidence map›Paper›PMID 19541911›Full record

ArticleGenome research2009

Circos: an information aesthetic for comparative genomics.

Martin Krzywinski, Jacqueline Schein, Inanç Birol, Joseph Connors, Randy Gascoyne, Doug Horsman, Steven J Jones, Marco A Marra

Abstract read
In one paragraph

Article in Genome research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6,469 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6,469citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6,469 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  12. Phenotypic divergence is driven by mobile genetic elements in a heritable insect symbiont.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  14. Unlocking the power ofmSystems · 2026
    Article
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6,409 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Martin KrzywinskiCanada's Michael Smith Genome Sciences Center, Vancouver, British Columbia V5Z 4S6, Canada. martink@bcgsc.ca
Jacqueline Schein
Inanç Birol
Joseph Connors
Randy Gascoyne
Doug Horsman
Steven J Jones
Marco A Marra

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We created a visualization tool called Circos to facilitate the identification and analysis of similarities and differences arising from comparisons of genomes. Our tool is effective in displaying variation in genome structure and, generally, any other kind of positional relationships between genomic intervals. Such data are routinely produced by sequence alignments, hybridization arrays, genome mapping, and genotyping studies. Circos uses a circular ideogram layout to facilitate the display of relationships between pairs of positions by the use of ribbons, which encode the position, size, and orientation of related genomic elements. Circos is capable of displaying data as scatter, line, and histogram plots, heat maps, tiles, connectors, and text. Bitmap or vector images can be created from GFF-style data inputs and hierarchical configuration files, which can be easily generated by automated tools, making Circos suitable for rapid deployment in data analysis and reporting pipelines.

Indexed as

GenomicsSoftwareAnimalsChromosome MappingChromosomes, Artificial, BacterialChromosomes, Human, Pair 17Chromosomes, Human, Pair 6Contig MappingDogsGene DosageGenomeHumansLymphoma, Follicular

Identifiers

PMID19541911
PMCPMC2752132

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.