ArticleProceedings of the National Academy of Sciences of the United States of America2009
Sporulation in mycobacteria.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 111 citations in OpenAlex.
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- Immunobiology of tubercle bacilli and prospects of immunomodulatory drugs to tackle tuberculosis (TB) and other non-tubercular mycobacterial infections.Immunobiology · 2022Review
- Drug resistant tuberculosis: Implications for transmission, diagnosis, and disease management.Frontiers in cellular and infection microbiology · 2022Review
- Ecological Adaptations of Gut Microbiota Members and Their Consequences for Use as a New Generation of Probiotics.International journal of molecular sciences · 2021Review
- Article
- From Root to Tips: Sporulation Evolution and Specialization in Bacillus subtilis and the Intestinal Pathogen Clostridioides difficile.Molecular biology and evolution · 2019Article
- Comparative genomics of Mycobacterium mucogenicum and Mycobacterium neoaurum clade members emphasizing tRNA and non-coding RNA.BMC evolutionary biology · 2019Article
- Adaptive Strategies in a Poly-Extreme Environment: Differentiation of Vegetative Cells inFrontiers in microbiology · 2019Article
- Delineating FtsQ-mediated regulation of cell division inThe Journal of biological chemistry · 2018Article
- Mycobacterial Cultures Contain Cell Size and Density Specific Sub-populations of Cells with Significant Differential Susceptibility to Antibiotics, Oxidative and Nitrite Stress.Frontiers in microbiology · 2017Article
- Thermal Inactivation of Mycobacterium avium subsp. paratuberculosis in Artificially Contaminated Milk by Direct Steam Injection.Applied and environmental microbiology · 2016Article
- Mild Nutrient Starvation Triggers the Development of a Small-Cell Survival Morphotype in Mycobacteria.Frontiers in microbiology · 2016Article
- Characterization of Three Mycobacterium spp. with Potential Use in Bioremediation by Genome Sequencing and Comparative Genomics.Genome biology and evolution · 2015Article
- Mycobacterial Growth.Cold Spring Harbor perspectives in medicine · 2015Review
- Bacterial solutions to multicellularity: a tale of biofilms, filaments and fruiting bodies.Nature reviews. Microbiology · 2014Review
- Highly Deviated Asymmetric Division in Very Low Proportion of Mycobacterial Mid-log Phase Cells.The open microbiology journal · 2014Article
- A genomic signature and the identification of new sporulation genes.Journal of bacteriology · 2013Article
- Genomic determinants of sporulation in Bacilli and Clostridia: towards the minimal set of sporulation-specific genes.Environmental microbiology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mycobacteria owe their success as pathogens to their ability to persist for long periods within host cells in asymptomatic, latent forms before they opportunistically switch to the virulent state. The molecular mechanisms underlying the transition into dormancy and emergence from it are not clear. Here we show that old cultures of Mycobacterium marinum contained spores that, upon exposure to fresh medium, germinated into vegetative cells and reappeared again in stationary phase via endospore formation. They showed many of the usual characteristics of well-known endospores. Homologues of well-known sporulation genes of Bacillus subtilis and Streptomyces coelicolor were detected in mycobacteria genomes, some of which were verified to be transcribed during appropriate life-cycle stages. We also provide data indicating that it is likely that old Mycobacterium bovis bacillus Calmette-Guérin cultures form spores. Together, our data show sporulation as a lifestyle adapted by mycobacteria under stress and tempt us to suggest this as a possible mechanism for dormancy and/or persistent infection. If so, this might lead to new prophylactic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.