ArticleProceedings of the National Academy of Sciences of the United States of America2009
The glucanosyltransferase Gas1 functions in transcriptional silencing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Article
- GPI-anchored Gas1 protein regulates cytosolic proteostasis in budding yeast.G3 (Bethesda, Md.) · 2024Article
- A role for β-1,6- and β-1,3-glucans in kinetochore function in Saccharomyces cerevisiae.Genetics · 2024Article
- GPI-anchored Gas1 protein regulates cytosolic proteostasis in yeast.bioRxiv : the preprint server for biology · 2023Article
- Metabolic regulation of telomere silencing by SESAME complex-catalyzed H3T11 phosphorylation.Nature communications · 2021Article
- VelA and LaeA are Key Regulators ofMicroorganisms · 2019Article
- The Beauveria bassiana Gas3 β-Glucanosyltransferase Contributes to Fungal Adaptation to Extreme Alkaline Conditions.Applied and environmental microbiology · 2018Article
- Screening for amyloid proteins in the yeast proteome.Current genetics · 2018Article
- The PHR Family: The Role of Extracellular Transglycosylases in Shaping Candida albicans Cells.Journal of fungi (Basel, Switzerland) · 2017Review
- Article
- Inferring orthologous gene regulatory networks using interspecies data fusion.Bioinformatics (Oxford, England) · 2015Article
- The β-1,3-glucanosyltransferase Gas1 regulates Sir2-mediated rDNA stability in Saccharomyces cerevisiae.Nucleic acids research · 2014Article
- Article
- Identification of a chloroplast ribonucleoprotein complex containing trans-splicing factors, intron RNA, and novel components.Molecular & cellular proteomics : MCP · 2013Article
- Mitotic exit and separation of mother and daughter cells.Genetics · 2012Review
- Palmitoylation controls the dynamics of budding-yeast heterochromatin via the telomere-binding protein Rif1.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Contribution of the gas1 gene of the entomopathogenic fungus Beauveria bassiana, encoding a putative glycosylphosphatidylinositol-anchored beta-1,3-glucanosyltransferase, to conidial thermotolerance and virulence.Applied and environmental microbiology · 2011Article
- Article
- Characterization of surface-exposed reactive cysteine residues in Saccharomyces cerevisiae.Biochemistry · 2010Article
- Fueling transcriptional silencing with Gas1.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
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2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transcriptional silencing is a crucial process that is mediated through chromatin structure. The histone deacetylase Sir2 silences genomic regions that include telomeres, ribosomal DNA (rDNA) and the cryptic mating-type loci. Here, we report an unsuspected role for the enzyme Gas1 in locus-specific transcriptional silencing. GAS1 encodes a beta-1,3-glucanosyltransferase previously characterized for its role in cell wall biogenesis. In gas1 mutants, telomeric silencing is defective and rDNA silencing is enhanced. We show that the catalytic activity of Gas1 is required for normal silencing, and that Gas1's role in silencing is distinct from its role in cell wall biogenesis. Established hallmarks of silent chromatin, such as Sir2 and Sir3 binding, H4K16 deacetylation, and H3K56 deacetylation, appear unaffected in gas1 mutants. Thus, another event required for telomeric silencing must be influenced by GAS1. Because the catalytic activity of Gas1 is required for telomeric silencing, Gas1 localizes to the nuclear periphery, and Gas1 and Sir2 physically interact, we propose a model in which carbohydrate modification of chromatin components provides a new regulatory element that may be critical for chromatin function but which is virtually unexplored in the current landscape of chromatin analysis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.