ArticleProceedings of the National Academy of Sciences of the United States of America2009
Influence of the coupling of interdomain and overall motions on NMR relaxation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Gel-Based NMR Method for Observing Submicrosecond Protein Dynamics at Atomic Resolution.The journal of physical chemistry letters · 2026Article
- Detection of intramolecular protein dynamics on nanosecond-to-microsecond timescales by nanoparticle-assisted NMR spin relaxation (NASR).Nature protocols · 2026Review
- NMR Spin Relaxation Theory of Biomolecules Undergoing Highly Asymmetric Exchange with Large Interaction Partners.Journal of chemical theory and computation · 2021Article
- A dynamic look backward and forward.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2016Review
- Investigating the Role of Large-Scale Domain Dynamics in Protein-Protein Interactions.Frontiers in molecular biosciences · 2016Review
- Article
- Distribution of Pico- and Nanosecond Motions in Disordered Proteins from Nuclear Spin Relaxation.Biophysical journal · 2015Article
- Functional dynamics in replication protein A DNA binding and protein recruitment domains.Structure (London, England : 1993) · 2015Article
- NMR studies of dynamic biomolecular conformational ensembles.Progress in nuclear magnetic resonance spectroscopy · 2015Review
- Local isotropic diffusion approximation for coupled internal and overall molecular motions in NMR spin relaxation.The journal of physical chemistry. B · 2014Article
- Nanosecond time scale motions in proteins revealed by high-resolution NMR relaxometry.Journal of the American Chemical Society · 2013Article
- Determining interdomain structure and dynamics of a retroviral capsid protein in the presence of oligomerization: implication for structural transition in capsid assembly.Biochemistry · 2013Article
- NMR relaxation in proteins with fast internal motions and slow conformational exchange: model-free framework and Markov state simulations.The journal of physical chemistry. B · 2013Article
- Activation of UbcH5c~Ub is the result of a shift in interdomain motions of the conjugate bound to U-box E3 ligase E4B.Biochemistry · 2013Article
- Sucrose in aqueous solution revisited, Part 2: adaptively biased molecular dynamics simulations and computational analysis of NMR relaxation.Biopolymers · 2012Article
- Exposing the Moving Parts of Proteins with NMR Spectroscopy.The journal of physical chemistry letters · 2012Article
- Coupling between internal dynamics and rotational diffusion in the presence of exchange between discrete molecular conformations.The Journal of chemical physics · 2012Article
- Theory of nonrigid rotational motion applied to NMR relaxation in RNA.The journal of physical chemistry. A · 2011Article
- Domain cooperativity in multidomain proteins: what can we learn from molecular alignment in anisotropic media?Journal of biomolecular NMR · 2011Article
- A direct coupling between global and internal motions in a single domain protein? MD investigation of extreme scenarios.Biophysical journal · 2011Article
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3 authors.
Funding
Abstract
Most theoretical models for NMR relaxation in liquids assume that overall rotational motion can be described as rotational diffusion with a single diffusion tensor. Such models cannot handle motions (such as between "closed" and "open" states of an enzyme, or between conformers of a partially disordered system) where the shape of the molecule (and hence its rotational diffusion behavior) fluctuates. We provide here a formalism for dealing with such problems. The model involves jumps between discrete conformers with different overall diffusion tensors, and a master (rate) equation to describe the transitions between these conformers. Numerical examples are given for a two-site jump model where global and local motions are concerted, showing how the rate of conformational transitions (relative to the rate of rotational diffusion) affects the observed relaxation parameters.
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