ArticleRespiratory physiology & neurobiology2009
Multiple pontomedullary mechanisms of respiratory rhythmogenesis.
Article in Respiratory physiology & neurobiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 87 citations in OpenAlex.
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- Postinspiratory complex acts as a gating mechanism regulating swallow-breathing coordination and other laryngeal behaviors.bioRxiv : the preprint server for biology · 2023Article
- Fentanyl effects on respiratory neuron activity in the dorsolateral pons.Journal of neurophysiology · 2022Article
- The intractable problems with brain death and possible solutions.Philosophy, ethics, and humanities in medicine : PEHM · 2021Review
- Calcium Imaging Analysis of Cellular Responses to Hypercapnia and Hypoxia in the NTS of Newborn Rat Brainstem Preparation.Frontiers in physiology · 2021Article
- The role of glycinergic inhibition in respiratory pattern formation and cardio-respiratory coupling in rats.Current research in physiology · 2021Article
- Near field non-invasive electrophysiology of retrotrapezoid nucleus using amperometric cation sensor.Biosensors & bioelectronics · 2020Article
- Correlation of Swallowing Function With Bilateral Diaphragmatic Movement in Hemiplegic Stroke Patients.Annals of rehabilitation medicine · 2019Article
- Possible Breathing Influences on the Control of Arterial Pressure After Sino-aortic Denervation in Rats.Current hypertension reports · 2018Review
- A Subregion of the Parabrachial Nucleus Partially Mediates Respiratory Rate Depression from Intravenous Remifentanil in Young and Adult Rabbits.Anesthesiology · 2017Article
- The human ventilatory response to stress: rate or depth?The Journal of physiology · 2017Review
- C57BL/6J mouse apolipoprotein A2 gene is deterministic for apnea.Respiratory physiology & neurobiology · 2017Article
- Proton detection and breathing regulation by the retrotrapezoid nucleus.The Journal of physiology · 2016Review
- Chronic Intermittent Hypoxia Alters Local Respiratory Circuit Function at the Level of the preBötzinger Complex.Frontiers in neuroscience · 2016Article
- Insular and caudate lesions release abnormal yawning in stroke patients.Brain structure & function · 2015Observational
- Respiratory modulation of sympathetic activity is attenuated in adult rats conditioned with chronic hypobaric hypoxia.Respiratory physiology & neurobiology · 2015Article
- Regulation of breathing and autonomic outflows by chemoreceptors.Comprehensive Physiology · 2014Review
- Physiological and pathophysiological interactions between the respiratory central pattern generator and the sympathetic nervous system.Progress in brain research · 2014Review
- Respiratory rhythm generation in vivo.Physiology (Bethesda, Md.) · 2014Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Mammalian central pattern generators producing rhythmic movements exhibit robust but flexible behavior. However, brainstem network architectures that enable these features are not well understood. Using precise sequential transections through the pons to medulla, it was observed that there was compartmentalization of distinct rhythmogenic mechanisms in the ponto-medullary respiratory network, which has rostro-caudal organization. The eupneic 3-phase respiratory pattern was transformed to a 2-phase and then to a 1-phase pattern as the network was physically reduced. The pons, the retrotrapezoid nucleus and glycine mediated inhibition are all essential for expression of the 3-phase rhythm. The 2-phase rhythm depends on inhibitory interactions (reciprocal) between Bötzinger and pre-Bötzinger complexes, whereas the 1-phase-pattern is generated within the pre-Bötzinger complex and is reliant on the persistent sodium current. In conditions of forced expiration, the RTN region was found to be essential for the expression of abdominal late expiratory activity. However, it is unknown whether the RTN generates or simply relays this activity. Entrained with the central respiratory network is the sympathetic nervous system, which exhibits patterns of discharge coupled with the respiratory cycle (in terms of both gain and phase of coupling) and dysfunctions in this coupling appear to underpin pathological conditions. In conclusion, the respiratory network has rhythmogenic capabilities at multiple levels of network organization, allowing expression of motor patterns specific for various physiological and pathophysiological respiratory behaviors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.