ReviewNeuroscience2009
Genetics of anxiety and trauma-related disorders.
Review in Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Association of Cigarette Smoking With Depression and Anxiety: A Systematic Review.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2017Pooled it
- Genome-wide association study of posttraumatic stress disorder in a cohort of Iraq-Afghanistan era veterans.Journal of affective disorders · 2015Pooled it
- Psychedelic therapies reconsidered: compounds, clinical indications, and cautious optimism.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Genome-wide translational profiling of amygdala Crh-expressing neurons reveals role for CREB in fear extinction learning.Nature communications · 2020Article
- Vesicular monoamine transporter 2 mediates fear behavior in mice.Genes, brain, and behavior · 2020Article
- COMT val158met polymorphism links to altered fear conditioning and extinction are modulated by PTSD and childhood trauma.Depression and anxiety · 2018Article
- Decreased Glutamatergic Activity in the Frontal Cortex of Single Prolonged Stress Model: In vivo and Ex Vivo Proton MR Spectroscopy.Neurochemical research · 2017Article
- miR-34b attenuates trauma-induced anxiety-like behavior by targeting CRHR1.International journal of molecular medicine · 2017Article
- Genetic approaches for the study of PTSD: Advances and challenges.Neuroscience letters · 2017Review
- Endocannabinoid signalling modulates susceptibility to traumatic stress exposure.Nature communications · 2017Article
- Forebrain glutamatergic, but not GABAergic, neurons mediate anxiogenic effects of the glucocorticoid receptor.Molecular psychiatry · 2017Article
- Negative Mood and Obsessive-Compulsive Related Clinical Constructs: An Examination of Underlying Factors.Frontiers in psychology · 2017Article
- Stress-related disorders, pituitary adenylate cyclase-activating peptide (PACAP)ergic system, and sex differences.Dialogues in clinical neuroscience · 2016Article
- Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches.Oxidative medicine and cellular longevity · 2016Review
- A role for Tac2, NkB, and Nk3 receptor in normal and dysregulated fear memory consolidation.Neuron · 2014Article
- Altered hippocampal function before emotional trauma in rats susceptible to PTSD-like behaviors.Neurobiology of learning and memory · 2014Article
- Genetic approaches to understanding post-traumatic stress disorder.The international journal of neuropsychopharmacology · 2014Review
- Zebrafish as an emerging model for studying complex brain disorders.Trends in pharmacological sciences · 2014Review
- Unpredictable neonatal stress enhances adult anxiety and alters amygdala gene expression related to serotonin and GABA.Neuroscience · 2014Article
- Translational reciprocity: bridging the gap between preclinical studies and clinical treatment of stress effects on the adolescent brain.Neuroscience · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Anxiety disorders are the most common psychiatric illnesses in the United States with approximately 30% of the population experiencing anxiety-related symptoms in their lifetime [Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE (2005) Lifetime prevalence and age-of-onset distributions of Diagnostic and Statistical Manual of Mental Disorders-IV (DSM-IV) disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62:593-60]. Notably, a variety of studies have demonstrated that 30-40% of the variance contributing to these disorders is heritable. In the present review, we discuss the latest findings regarding the genetic and environmental influences on the development and symptomatology of anxiety disorders. Specific emphasis is placed on posttraumatic stress disorder (PTSD) due to its uniqueness as an anxiety disorder; its diagnosis is dependent on a precipitating traumatic event and its development appears to be mediated by both genetic and environmental contributions. The co-morbidity of anxiety disorders and the potential re-classification of anxiety disorders as part of DSM-V are reviewed given the potential impact on the interpretation and design of genetic investigations. Lastly, several keys to future genetic studies are highlighted. Thorough analyses of the gene by environment (GxE) interactions that govern one's vulnerability to anxiety disorder(s), the effectiveness of individual treatment strategies, and the severity of symptoms may lead to more effective prophylactic (e.g. social support) and treatment strategies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.