ArticleCurrent biology : CB2009
Sulfation of eggshell components by Pipe defines dorsal-ventral polarity in the Drosophila embryo.
Article in Current biology : CB, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Finishing the egg.Genetics · 2024Article
- Vitelline Membrane Protein 26 Mutagenesis, Using CRISPR/Cas9, Results in Egg Collapse inInternational journal of molecular sciences · 2022Article
- Disproportionate investment in Spiralin B production limits in-host growth and favors the vertical transmission ofProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Expression and Function of Toll Pathway Components in the Early Development of the WaspJournal of developmental biology · 2022Article
- Article
- A single-cell atlas of adult Drosophila ovary identifies transcriptional programs and somatic cell lineage regulating oogenesis.PLoS biology · 2020Article
- Transfer of Dorsoventral and Terminal Information from the Ovary to the Embryo by a Common Group of Eggshell Proteins inGenetics · 2017Article
- A ventrally localized protease in the Drosophila egg controls embryo dorsoventral polarity.Current biology : CB · 2012Article
- Molecular mechanisms of EGF signaling-dependent regulation of pipe, a gene crucial for dorsoventral axis formation in Drosophila.Development genes and evolution · 2012Article
- The evolution of dorsal-ventral patterning mechanisms in insects.Genes & development · 2011Review
- Drosophila vitelline membrane assembly: a critical role for an evolutionarily conserved cysteine in the "VM domain" of sV23.Developmental biology · 2010Article
- Article
- Activation of Snake in a serine protease cascade that defines the dorsoventral axis is atypical and pipe-independent in Drosophila embryos.FEBS letters · 2010Article
- Pipe-dependent ventral processing of Easter by Snake is the defining step in Drosophila embryo DV axis formation.Current biology : CB · 2010Article
- Maternal control of the Drosophila dorsal-ventral body axis.Wiley interdisciplinary reviews. Developmental biologyReview
- Article
- Comparisons of the embryonic development of Drosophila, Nasonia, and Tribolium.Wiley interdisciplinary reviews. Developmental biologyArticle
- EGFR-dependent downregulation of Capicua and the establishment of Drosophila dorsoventral polarity.FlyArticle
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Abstract
Drosophila embryonic dorsal-ventral (DV) polarity is controlled by a group of sequentially acting serine proteases located in the fluid-filled perivitelline space between the embryonic membrane and the eggshell, which generate the ligand for the Toll receptor on the ventral side of the embryo. Spatial control of the protease cascade relies on the Pipe sulfotransferase, a fly homolog of vertebrate glycosaminoglycan-modifying enzymes, which is expressed in ventral cells of the follicular epithelium surrounding the developing oocyte. Here we show that the vitelline membrane-like (VML) protein undergoes Pipe-dependent sulfation and, consistent with a role in conveying positional information from the egg chamber to the embryo, becomes incorporated into the eggshell at a position corresponding to the location of the follicle cells from which it was secreted. Although VML influences embryonic DV pattern in a sensitized genetic background, VML is not essential for DV axis formation, suggesting that there is redundancy in the composition of the Pipe enzymatic target. Correspondingly, we find that additional structural components of the vitelline membrane undergo Pipe-dependent sulfation. In identifying the elusive targets of Pipe, this work points to the vitelline membrane as the source of signals that generate the Drosophila DV axis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.