ArticleVirology2009
CD8+ T cell immunodominance shifts during the early stages of acute LCMV infection independently from functional avidity maturation.
Article in Virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- PSGL-1 attenuates early TCR signaling to suppress CD8Cell reports · 2023Article
- Immunogenicity of Pfizer mRNA COVID-19 Vaccination Followed by J&J Adenovirus COVID-19 Vaccination in Two Patients with Chronic Lymphocytic Leukemia.Case reports in hematology · 2022Article
- Cross-serotypically conserved epitope recommendations for a universal T cell-based dengue vaccine.PLoS neglected tropical diseases · 2020Article
- Expression of Viral Antigen by the Liver Leads to Chronic Infection Through the Generation of Regulatory T Cells.Cellular and molecular gastroenterology and hepatology · 2015Article
- In vivo modulation of avidity in highly sensitive CD8(+) effector T cells following viral infection.Viral immunology · 2013Article
- Quantifying T lymphocyte turnover.Journal of theoretical biology · 2013Article
- Characterization of CD8+ T cell function and immunodominance generated with an H2O2-inactivated whole-virus vaccine.Journal of virology · 2012Article
- Changes in functional but not structural avidity during differentiation of CD8+ effector cells in vivo after virus infection.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling.The American journal of pathology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Virus-specific T cell responses are often directed to a small subset of possible epitopes and their relative magnitude defines their hierarchy. We determined the size and functional avidity of 4 representative peptide-specific CD8(+) T cell populations in C57BL/6 mice at different time points after lymphocytic choriomeningitis virus (LCMV) infection. We found that the frequency of different peptide-specific T cell populations in the spleen changed independently over the first 8 days after infection. These changes were not associated with a larger or more rapid increase in functional avidity and yet still resulted in a shift in the final immunodominance hierarchy. Thus, the immunodominance observed at the peak of an antiviral T cell response is not necessarily determined by the initial size or rate of functional avidity maturation of peptide-specific T cell populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.