ArticleRespiratory physiology & neurobiology2009
Electromyographic activity at the base and tip of the tongue across sleep-wake states in rats.
Article in Respiratory physiology & neurobiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Noradrenergic terminal density varies among different groups of hypoglossal premotor neurons.Journal of chemical neuroanatomy · 2019Article
- Modulation of Motoneuronal Activity With Sleep-Wake States and Motoneuronal Gene Expression Vary With Circadian Rest-Activity Cycle.Frontiers in integrative neuroscience · 2018Article
- Hypoglossal motoneurons are endogenously activated by serotonin during the active period of circadian cycle.Respiratory physiology & neurobiology · 2018Article
- Neural Control of the Upper Airway: Respiratory and State-Dependent Mechanisms.Comprehensive Physiology · 2016Review
- Intranodose ganglion injections of dronabinol attenuate serotonin-induced apnea in Sprague-Dawley rat.Respiratory physiology & neurobiology · 2014Article
- Lingual muscle activity across sleep-wake States in rats with surgically altered upper airway.Frontiers in neurology · 2014Article
- Time- and behavioral state-dependent changes in posterior hypothalamic GABAA receptors contribute to the regulation of sleep.PloS one · 2014Article
- Circadian dependence of receptors that mediate wake-related excitatory drive to hypoglossal motoneurons.Respiratory physiology & neurobiology · 2013Article
- Respiratory modulation of lingual muscle activity across sleep-wake states in rats.Respiratory physiology & neurobiology · 2013Article
- Spontaneous sleep-like brain state alternations and breathing characteristics in urethane anesthetized mice.PloS one · 2013Article
- Reduced sleep and impaired sleep initiation in adult male rats exposed to alcohol during early postnatal period.Behavioural brain research · 2012Article
- State-dependent modulation of breathing in urethane-anesthetized rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Ketamine activates breathing and abolishes the coupling between loss of consciousness and upper airway dilator muscle dysfunction.Anesthesiology · 2012Article
- Quantitative differences among EMG activities of muscles innervated by subpopulations of hypoglossal and upper spinal motoneurons during non-REM sleep - REM sleep transitions: a window on neural processes in the sleeping brain.Archives italiennes de biologie · 2011Article
- Respiratory related control of hypoglossal motoneurons--knowing what we do not know.Respiratory physiology & neurobiology · 2011Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Obstructive sleep apnea (OSA) patients have elevated tonic and phasic inspiratory activity in the genioglossus and other upper airway muscles during wakefulness; this protects their upper airway from collapse. In this group, sleep-related decrements of upper airway motor tone result in sleep-related upper airway obstructions. We previously reported that in the rat, a species widely used to study the neural mechanisms of both sleep and breathing, lingual electromyographic activity (EMG) is minimal or absent during slow-wave sleep (SWS) and then gradually increases after the onset of rapid eye movement sleep (REMS) due to the appearance of large phasic bursts. Here, we investigated whether sleep-wake patterns and respiratory modulation of lingual EMG depend on the site of EMG recording within the tongue. In nine chronically instrumented rats, we recorded from 17 sites within the tongue and from the diaphragm across sleep-wake states. We quantified lingual EMG in successive 10s intervals of continuous 2h recordings (1-3 p.m.). We found that sleep-wake patterns of lingual EMG did not differ between the base and tip of the tongue, and that respiratory modulation was extremely rare regardless of the recording site. We also determined that the often rhythmic lingual bursts during REMS do not occur with respiratory rhythmicity. This pattern differs from that in OSA subjects who, unlike rats, have collapsible upper airway, exhibit prominent respiratory modulation of upper airway motor tone during quiet wakefulness, retain considerable tonic and inspiratory phasic activity during SWS, and show nadirs of activity during REMS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.