ArticleNeuroscience2009
Brainstem control of cerebral blood flow and application to acute vasospasm following experimental subarachnoid hemorrhage.
Article in Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Cellular Mechanisms Underlying Endothelial and Histopathological Alterations Induced by Cerebral Angiography.Journal of clinical medicine · 2026Review
- Animal Welfare Aspects in Planning and Conducting Experiments on Rodent Models of Subarachnoid Hemorrhage.Cellular and molecular neurobiology · 2023Review
- In a model of SAH-induced neurogenic fever, BAT thermogenesis is mediated by erythrocytes and blocked by agonism of adenosine A1 receptors.Scientific reports · 2021Article
- Pericytes: Intrinsic Transportation Engineers of the CNS Microcirculation.Frontiers in physiology · 2021Review
- Susceptibility of Primary Sensory Cortex to Spreading Depolarizations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Multimodal MRI characterization of experimental subarachnoid hemorrhage.Neuroscience · 2016Article
- Review of optical coherence tomography based angiography in neuroscience.Neurophotonics · 2016Review
- Brainstem opioidergic system is involved in early response to experimental SAH.Translational stroke research · 2015Article
- Increased sleep need and daytime sleepiness 6 months after traumatic brain injury: a prospective controlled clinical trial.Brain : a journal of neurology · 2015Article
- The identification and neurochemical characterization of central neurons that target parasympathetic preganglionic neurons involved in the regulation of choroidal blood flow in the rat eye using pseudorabies virus, immunolabeling and conventional pathway tracing methods.Frontiers in neuroanatomy · 2015Article
- The inhibition of neurons in the central nervous pathways for thermoregulatory cold defense induces a suspended animation state in the rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Symptomatic ischemia following aneurysmal subarachnoid hemorrhage (SAH) is common but poorly understood and inadequately treated. Severe constriction of the major arteries at the base of the brain, termed vasospasm, traditionally has been thought to be a proximal event underlying these ischemias, although microvascular changes also have been described. The vast majority of studies aimed at understanding the pathogenesis of ischemic deficits, and vasospasm have focused on the interaction of the "spasmogen" of the extravasated blood with the smooth muscle and endothelium of the arteries. This has led to a comparative neglect of the contribution of the CNS to the maintenance of cerebral perfusion. In the present study, we focused on the role of the rostral ventromedial medulla (RVM) in modulating cerebral perfusion at rest and following an experimental SAH in the rat. Changes in cerebral blood flow (CBF) were measured using laser-Doppler flowmetry and three-dimensional optical microangiography. Focal application of a GABA(A) receptor agonist and antagonist was used to respectively inactivate and activate the RVM. We show here that the RVM modulates cerebral blood flow under resting conditions, and further, contributes to restoration of cerebral perfusion following a high-grade SAH. Failure of this brainstem compensatory mechanism could be significant for acute perfusion deficits seen in patients following subarachnoid hemorrhage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.