Trial reportBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation2009
Allogeneic hematopoietic cell transplantation in human immunodeficiency virus-positive patients with hematologic disorders: a report from the center for international blood and marrow transplant research.
Trial report in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: a global perspective.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2009Guideline
- Allogeneic Hematopoietic Cell Transplant for HIV Patients with Hematologic Malignancies: The BMT CTN-0903/AMC-080 Trial.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2019Trial
- Haemopoietic cell transplantation in patients living with HIV.The lancet. HIV · 2020Review
- The Changing Landscape of Lymphoma Associated with HIV Infection.Current oncology reports · 2020Review
- Optimizing treatment of HIV-associated lymphoma.Blood · 2019Review
- A Brazilian university hospital position regarding transplantation criteria for HIV-positive patients according to the current literature.Clinics (Sao Paulo, Brazil) · 2019Review
- Hiv and Lymphoma: from Epidemiology to Clinical Management.Mediterranean journal of hematology and infectious diseases · 2019Review
- Graft-versus-leukaemia effect post fludarabine, melphalan and alemtuzumab reduced intensity allogeneic stem cell transplantat in HIV-infected patient with acute myeloid leukaemia.Bone marrow transplantation · 2018Article
- Allogeneic stem cell transplantation for HIV-positive patients with hematologic malignancies.AIDS (London, England) · 2016Article
- Hematopoietic stem cell transplantation for HIV cure.The Journal of clinical investigation · 2016Review
- HIV and Stem Cell Transplantation.Current infectious disease reports · 2014Article
- The role of hematopoietic SCT in adult Burkitt lymphoma.Bone marrow transplantation · 2013Review
- Significant interaction of tacrolimus with ritonavir during allogeneic hematopoietic SCT in an HIV-infected patient.Bone marrow transplantation · 2012Article
- HIV-Associated Hodgkin's Lymphoma: Prognosis and Therapy in the Era of cART.Advances in hematology · 2012Article
- Graft versus host disease in the bone marrow, liver and thymus humanized mouse model.PloS one · 2012Article
- Allogeneic haematopoietic stem cell transplantation in patients with human immunodeficiency virus: the experiences of more than 25 years.Clinical and experimental immunology · 2011Review
- Hematopoietic stem cell transplantation for AIDS-related malignancies.Current opinion in oncology · 2010Review
- How we approach patient evaluation for hematopoietic stem cell transplantation.Bone marrow transplantation · 2010Review
- Hematopoietic stem cell transplantation in patients infected with HIV.Current HIV/AIDS reports · 2010Review
- Allo-SCT for hematological malignancies in the setting of HIV.Bone marrow transplantation · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 11 institutions in 4 countries.
Funding
Abstract
The role of allogeneic hematopoietic cell transplantation (alloHCT) in human immunodeficiency virus (HIV)-positive patients is not known. Using the Center for International Blood and Marrow Transplant Research database, we retrospectively evaluated 23 HIV-positive patients undergoing matched sibling donor (n = 19) or unrelated donor (n = 4) alloHCT between 1987 and 2003. The median age at alloHCT was 32 years. Indications for alloHCT were diverse and included malignant (n = 21) and nonmalignant (n = 2) hematologic disorders. Nine patients (39%) underwent transplantation after 1996, the approximate year that highly active antiretroviral therapy became standard treatment. The median time to neutrophil engraftment was 16 days (range, 7 to 30 days), and the cumulative incidences of grade II-IV acute graft-versus-host disease (aGVHD) at 100 days, chronic GVHD (cGVHD), and survival at 2 years were 30% (95% confidence interval [CI] = 14% to 50%), 28% (95% CI = 12% to 48%), and 30% (95% CI = 14% to 50%), respectively. At a median follow-up of 59 months, 6 patients were alive. Survival appears to be better in the patients undergoing alloHCT after 1996; 4 of these 9 patients survived, compared with only 2 of 14 those undergoing transplantation before 1996. These data suggest that alloHCT is feasible for selected HIV-positive patients with malignant and nonmalignant disorders. Prospective studies are needed to evaluate the safety and efficacy of this modality in specific diseases in these patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.