ArticleJournal of biomedical informatics2009
Computing with evidence Part II: An evidential approach to predicting metabolic drug-drug interactions.
Article in Journal of biomedical informatics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Developing a Knowledge Graph for Pharmacokinetic Natural Product-Drug Interactions.Journal of biomedical informatics · 2023Article
- Translational Knowledge Discovery Between Drug Interactions and Pharmacogenetics.Clinical pharmacology and therapeutics · 2020Review
- Translational Biomedical Informatics and Pharmacometrics Approaches in the Drug Interactions Research.CPT: pharmacometrics & systems pharmacology · 2018Review
- Leveraging syntactic and semantic graph kernels to extract pharmacokinetic drug drug interactions from biomedical literature.BMC systems biology · 2016Article
- Adding evidence type representation to DIDEO.CEUR workshop proceedings · 2016Article
- Toward a complete dataset of drug-drug interaction information from publicly available sources.Journal of biomedical informatics · 2015Article
- Consensus recommendations for systematic evaluation of drug-drug interaction evidence for clinical decision support.Drug safety · 2015Article
- Extraction of pharmacokinetic evidence of drug-drug interactions from the literature.PloS one · 2015Article
- Towards a foundational representation of potential drug-drug interaction knowledge.CEUR workshop proceedings · 2014Article
- The SADI Personal Health Lens: A Web Browser-Based System for Identifying Personally Relevant Drug Interactions.JMIR research protocols · 2013Article
- Informatics confronts drug-drug interactions.Trends in pharmacological sciences · 2013Review
- Dynamic enhancement of drug product labels to support drug safety, efficacy, and effectiveness.Journal of biomedical semantics · 2013Article
- Literature based drug interaction prediction with clinical assessment using electronic medical records: novel myopathy associated drug interactions.PLoS computational biology · 2012Article
- Deriving rules and assertions from pharmacogenomics knowledge resources in support of patient drug metabolism efficacy predictions.Journal of the American Medical Informatics Association : JAMIAArticle
- High-priority drug-drug interactions for use in electronic health records.Journal of the American Medical Informatics Association : JAMIAArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We describe a novel experiment that we conducted with the Drug Interaction Knowledge-base (DIKB) to determine which combinations of evidence enable a rule-based theory of metabolic drug-drug interactions to make the most optimal set of predictions. The focus of the experiment was a group of 16 drugs including six members of the HMG-CoA-reductase inhibitor family (statins). The experiment helped identify evidence-use strategies that enabled the DIKB to predict significantly more interactions present in a validation set than the most rigorous strategy developed by drug experts with no loss of accuracy. The best-performing strategies included evidence types that would normally be of lesser predictive value but that are often more accessible than more rigorous types. Our experimental methods represent a new approach to leveraging the available scientific evidence within a domain where important evidence is often missing or of questionable value for supporting important assertions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.