ArticleVaccine2009
The mycobacterial glycolipid glucose monomycolate induces a memory T cell response comparable to a model protein antigen and no B cell response upon experimental vaccination of cattle.
Article in Vaccine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids.Nature communications · 2025Article
- Role of Group 1 CD1-Restricted T Cells in Host Defense and Inflammatory Diseases.Critical reviews in immunology · 2021Article
- T Cell Responses to Mycobacterial Glycolipids: On the Spectrum of "Innateness".Frontiers in immunology · 2020Review
- Validation of a CD1b tetramer assay for studies of human mycobacterial infection or vaccination.Journal of immunological methods · 2018Article
- Dairy Cows Naturally Infected with Bovine Leukemia Virus Exhibit Abnormal B- and T-Cell Phenotypes after Primary and Secondary Exposures to Keyhole Limpet Hemocyanin.Frontiers in veterinary science · 2017Article
- T Cell Responses against Mycobacterial Lipids and Proteins Are Poorly Correlated in South African Adolescents.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- CD1 and mycobacterial lipids activate human T cells.Immunological reviews · 2015Review
- Expression patterns of bovine CD1 in vivo and assessment of the specificities of the anti-bovine CD1 antibodies.PloS one · 2015Article
- Targeted delivery of mycobacterial antigens to human dendritic cells via Siglec-7 induces robust T cell activation.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Nonclassical T cells and their antigens in tuberculosis.Cold Spring Harbor perspectives in medicine · 2014Review
- The T-Cell Response to Lipid Antigens of Mycobacterium tuberculosis.Frontiers in immunology · 2014Review
- Major T cell response to a mycolyl glycolipid is mediated by CD1c molecules in rhesus macaques.Infection and immunity · 2013Article
- Exogenous control of the expression of Group I CD1 molecules competent for presentation of microbial nonpeptide antigens to human T lymphocytes.Clinical & developmental immunology · 2011Review
- Crystal structure of bovine CD1b3 with endogenously bound ligands.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Glycolipids are presented to T cells by human group 1 CD1 proteins, but are not used as subunit vaccines yet. Experimental immunizations with pure mycobacterial glucose monomycolate (GMM) and keyhole limpet haemocyanin (KLH) in cattle, a species which, unlike mice, expresses group 1 CD1, showed that GMM was equally efficient as KLH in generating T cell responses in blood, but not in the draining lymph node. Also, KLH induced strong antibody responses whereas GMM did not. These data suggest that non-overlapping T cell populations are targeted and demonstrate the potential of glycolipids as a special class of subunit vaccine candidates.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.