ArticleVirology journal2009
The complete genome of klassevirus - a novel picornavirus in pediatric stool.
Article in Virology journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Who cites it
85 citing papers in PubMed.
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- Gut virome in early life: origins and implications.Current opinion in virology · 2022Review
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- Epidemiology, Genetic Characterization, and Evolution ofPathogens (Basel, Switzerland) · 2021Article
- Linking Virus Discovery to Immune Responses Visualized during Zebrafish Infections.Current biology : CB · 2020Article
- Molecular Detection of Human Salivirus in Italy Through Monitoring of Urban Sewages.Food and environmental virology · 2020Article
- Occurrence of Salivirus in Sewage and River Water Samples in Karaj, Iran.Food and environmental virology · 2019Article
- Infection and Propagation of Astrovirus VA1 in Cell Culture.Current protocols in microbiology · 2019Article
- Near full length genome of a recombinant (E/D) cosavirus strain from a rural area in the central region of Brazil.Scientific reports · 2018Article
- A decade of RNA virus metagenomics is (not) enough.Virus research · 2018Review
- Assessment and Evaluation of an Integrated Hybrid Anaerobic-Aerobic Sewage Treatment System for the Removal of Enteric Viruses.Food and environmental virology · 2017Article
- Acute West Nile Virus Meningoencephalitis Diagnosed Via Metagenomic Deep Sequencing of Cerebrospinal Fluid in a Renal Transplant Patient.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2017Article
- How much reduction of virus is needed for recycled water: A continuous changing need for assessment?Water research · 2017Review
- Rapid Metagenomic Next-Generation Sequencing during an Investigation of Hospital-Acquired Human Parainfluenza Virus 3 Infections.Journal of clinical microbiology · 2017Article
- First report of human salivirus/klassevirus in respiratory specimens of a child with fatal adenovirus infection.Virus genes · 2016Article
- Complete Genome Sequence of a Salivirus in Respiratory Specimens from a Child with Adenovirus Infection.Genome announcements · 2016Article
- Characterization of a Salivirus (Picornaviridae) from a Diarrheal Child in Guatemala.Genome announcements · 2016Article
25 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
backgroundDiarrhea kills 2 million children worldwide each year, yet an etiological agent is not found in approximately 30-50% of cases. Picornaviral genera such as enterovirus, kobuvirus, cosavirus, parechovirus, hepatovirus, teschovirus, and cardiovirus have all been found in human and animal diarrhea. Modern technologies, especially deep sequencing, allow rapid, high-throughput screening of clinical samples such as stool for new infectious agents associated with human disease.
resultsA pool of 141 pediatric gastroenteritis samples that were previously found to be negative for known diarrheal viruses was subjected to pyrosequencing. From a total of 937,935 sequence reads, a collection of 849 reads distantly related to Aichi virus were assembled and found to comprise 75% of a novel picornavirus genome. The complete genome was subsequently cloned and found to share 52.3% nucleotide pairwise identity and 38.9% amino acid identity to Aichi virus. The low level of sequence identity suggests a novel picornavirus genus which we have designated klassevirus. Blinded screening of 751 stool specimens from both symptomatic and asymptomatic individuals revealed a second positive case of klassevirus infection, which was subsequently found to be from the index case's 11-month old twin.
conclusionWe report the discovery of human klassevirus 1, a member of a novel picornavirus genus, in stool from two infants from Northern California. Further characterization and epidemiological studies will be required to establish whether klasseviruses are significant causes of human infection.
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