ArticleAnnals of the New York Academy of Sciences2009
Enteral versus parenteral nutrition: effect on intestinal barrier function.
Article in Annals of the New York Academy of Sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Efficacy of early enteral nutrition in patients with traumatic brain injury: a systematic review and meta-analysis.Frontiers in nutrition · 2026Pooled it
- Liver-protecting effects of omega-3 fish oil lipid emulsion in liver transplantation.World journal of gastroenterology · 2012Trial
- Reducing Complications in Pancreaticoduodenectomy.Cancers · 2026Review
- Research Progress of Sepsis and Nutrition: A Bibliometric and Visualized Analysis.Journal of inflammation research · 2026Article
- Enhanced recovery after surgery protocols in gastrectomy with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for gastric cancer.World journal of clinical oncology · 2025Review
- A medium-chain fatty acid analogue prevents endotoxin liver injury in a murine model.Scientific reports · 2025Article
- Altered hepatic and intestinal homeostasis in a neonatal murine model of short-term total parenteral nutrition and antibiotics.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Article
- Recommendations for the establishment and operation of a donor human milk bank.Nutrition reviews · 2023Article
- Nutritional Management of Intestinal Failure due to Short Bowel Syndrome in Children.Nutrients · 2022Review
- The Pathology and Physiology of Ileostomy.Frontiers in nutrition · 2022Review
- Nutrition and the gut microbiome during critical illness: A new insight of nutritional therapy.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2020Review
- Nutritional Feeding Strategies in Pediatric Intestinal Failure.Nutrients · 2020Review
- What do we know about optimal nutritional strategies in children with pediatric acute respiratory distress syndrome?Annals of translational medicine · 2019Review
- Application value of nursing intervention combined with early nutritional support in preventive stoma reversion of low rectal cancer.Oncology letters · 2019Article
- Observational
- Benefit of feeding tube placement for refractory malnutrition after bariatric surgery.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2018Article
- Feeding strategies in pediatric cancer patients with gastrointestinal mucositis: a multicenter prospective observational study and international survey.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017Observational
- Gastrointestinal immune and microbiome changes during parenteral nutrition.American journal of physiology. Gastrointestinal and liver physiology · 2017Review
- Green Tea Induced Cellular Proliferation and the Expression of Transforming Growth Factor-β1 in the Jejunal Mucosa of Fasting Rats.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
Total parenteral nutrition (TPN), or the complete absence of enteral nutrients, is commonly used in a clinical setting. However, a major consequence of TPN administration is the development of mucosal atrophy and a loss of epithelial barrier function (EBF); and this loss may lead to an increase in clinical infections and septicemia. Our laboratory has investigated the mechanism of this TPN-associated loss of EBF using a mouse model. We have demonstrated that the mucosal lymphoid population significantly changes with TPN, and leads to a rise in interferon gamma (IFN-gamma) and decline in interleukin-10 (IL-10) expression-both of which contribute to the loss of EBF. Associated with these cytokine changes is a dramatic decline in the expression of tight junction and adherens junction proteins. This article discusses the potential mechanisms responsible for these changes, and potential strategies to alleviate this loss in EBF.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.