ArticleStem cells and development2009
Inner cell mass localization of NANOG precedes OCT3/4 in rhesus monkey blastocysts.
Article in Stem cells and development, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 32 citations in OpenAlex.
- The unknown human trophectoderm: implication for biopsy at the blastocyst stage.Journal of assisted reproduction and genetics · 2020Review
- KLF4 Nuclear Export Requires ERK Activation and Initiates Exit from Naive Pluripotency.Stem cell reports · 2018Article
- Secretome of in vitro cultured human embryos contains extracellular vesicles that are uptaken by the maternal side.Scientific reports · 2017Article
- Germ cell specification and pluripotency in mammals: a perspective from early embryogenesis.Reproductive medicine and biology · 2014Article
- Trophoblast lineage cells derived from human induced pluripotent stem cells.Biochemical and biophysical research communications · 2013Article
- Generation of embryonic stem cell lines from immature rabbit ovarian follicles.Stem cells and development · 2013Article
- Trophoblast stem cells.Biology of reproduction · 2011Review
- Molecular mechanisms of pluripotency and reprogramming.Stem cell research & therapy · 2010Review
- Ontological aspects of pluripotency and stemness gene expression pattern in the rhesus monkey.Gene expression patterns : GEPArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
The mechanism by which the inner cell mass (ICM) and trophectoderm (TE) become specified is poorly understood. Considerable species variation is evident in the expression of lineage-specific and embryonic stem cell (ESC) regulatory markers. We sought to investigate localization patterns of these markers in rhesus macaque compact morulae and blastocysts. NANOG protein was restricted to the ICM of blastocysts. In contrast to a previous report, the expression of CDX2 was detected in the primate blastocyst, localized specifically to the TE. Unlike the mouse embryo, OCT4 protein was detected using two different antibodies in both the ICM and TE. The ubiquitous pattern of OCT4 expression is consistent with observations in human, cow, and pig embryos. Significantly, lack of restricted OCT4 protein, and ICM localization of NANOG in primate blastocysts, suggests that NANOG may determine inner cell mass fate more specifically during primate development or may be less susceptible to culture artifacts. These results contrast markedly with current mechanistic hypotheses, although other factors may lie upstream of NANOG to constitute a complex interactive network. This difference may also underlie observations that regulatory mechanisms in ESC differ between mice and primates.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.