ArticleCancer2009
Low-grade gliomas in older patients: long-term follow-up from Mayo Clinic.
Article in Cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- The role of radiotherapy in the management of patients with diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline.Journal of neuro-oncology · 2015Guideline
- Age-related risk factors and treatment outcomes in geriatric patients with spinal low-grade glioma: A nationwide analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Wild-Type TP53 Predicts Poor Prognosis in Lower-Grade Glioma via TP53-CXCL14-GATA3 Axis.Journal of molecular neuroscience : MN · 2025Article
- Epidemiological profile of adult primary brain tumors.Surgical neurology international · 2025Article
- Low-Grade Gliomas: Histological Subtypes, Molecular Mechanisms, and Treatment Strategies.Brain sciences · 2023Review
- Isocitrate-dehydrogenase-mutant lower grade glioma in elderly patients: treatment and outcome in a molecularly characterized contemporary cohort.Journal of neuro-oncology · 2023Article
- Patients' Survival with Astrocytoma After Treatment: a Systematic Review and Meta-analysis of Clinical Trial Studies.Indian journal of surgical oncology · 2022Review
- Age is associated with unfavorable neuropathological and radiological features and poor outcome in patients with WHO grade 2 and 3 gliomas.Scientific reports · 2021Article
- Racial/ethnic, socioeconomic, and geographic survival disparities in adolescents and young adults with primary central nervous system tumors.Pediatric blood & cancer · 2021Article
- DynamicNeuro-oncology practice · 2020Article
- Adult Diffuse Low-Grade Gliomas: 35-Year Experience at the Nancy France Neurooncology Unit.Frontiers in oncology · 2020Article
- Is it all a matter of size? Impact of maximization of surgical resection in cerebral tumors.Neurosurgical review · 2019Review
- Tumor recurrence patterns after surgical resection of intracranial low-grade gliomas.Journal of neuro-oncology · 2019Article
- Molecular features and clinical outcomes in surgically treated low-grade diffuse gliomas in patients over the age of 60.Journal of neuro-oncology · 2019Article
- Prognosis of older patients with low-grade glioma: A retrospective study.Integrative cancer science and therapeutics · 2017Article
- Patterns of care and treatment outcomes in older adults with low grade glioma: a 50-year experience.Journal of neuro-oncology · 2017Article
- Management of elderly patients with gliomas.The oncologist · 2014Review
- A population-based study of low-grade gliomas and mutated isocitrate dehydrogenase 1 (IDH1).Journal of neuro-oncology · 2013Article
- Efficacy of vagus nerve stimulation in brain tumor-associated intractable epilepsy and the importance of tumor stability.Journal of neurosurgery · 2013Article
- IDH mutations as an early and consistent marker in low-grade astrocytomas WHO grade II and their consecutive secondary high-grade gliomas.Journal of neuro-oncology · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundLow-grade gliomas (LGGs) are uncommon in older patients, and long-term clinical behavior and prognostic factors are not well defined in this group.
methodsThe authors retrospectively searched their tumor registry for the records of adult patients (> or =18 years) diagnosed as having nonpilocytic LGG between 1960 and 1992 at Mayo Clinic. The Kaplan-Meier method was used to estimate progression-free survival and overall survival (OS) in patients aged 55 years and older.
resultsOf 314 patients initially identified, 32 were aged at least 55 years, with a median age at diagnosis of 61 years (range, 55-74 years). Median follow-up was 17.3 years for survivors. Operative pathologic diagnoses comprised astrocytoma (n = 22, 69%), mixed oligoastrocytoma (n = 7, 22%), and oligodendroglioma (n = 3, 9%). Gross total resection was achieved in 1 patient, radical subtotal resection in 1, and subtotal resection in 14; 16 patients had biopsy only. Postoperative radiotherapy or chemotherapy was given to 23 (72%) patients and 1 (3%) patient, respectively. Median OS was 2.7 years for all patients: 3 years with resection and 2.2 years with biopsy only (P = .58). The 5- and 10-year OS rates were 31% and 18%, respectively. Factors adversely affecting OS on univariate analysis were enhancement on computed tomography (P < .001) and supratentorial location (P = .03).
conclusionsThis retrospective series of older patients suggests that intracranial LGG in this age group behaves aggressively. Pathologic sampling error failing to recognize higher-grade tumors does not seem to account for these poor outcomes. Aggressive management with maximally safe resection followed by adjuvant therapy should be strongly considered.
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