ArticleJournal of biomedical materials research. Part A2010
Characterization of pH-responsive hydrogels of poly(itaconic acid-g-ethylene glycol) prepared by UV-initiated free radical polymerization as biomaterials for oral delivery of bioactive agents.
Article in Journal of biomedical materials research. Part A, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Review
- In situ product removal via reactive extraction in itaconic acid fermentation with Ustilago cynodontis.Biotechnology for biofuels and bioproducts · 2026Article
- Fabrication of Functional Polymers with Gradual Release of a Bioactive Precursor for Agricultural Applications.Gels (Basel, Switzerland) · 2025Article
- Preparation, Swelling, and Drug Release Studies of Chitosan-based Hydrogels for Controlled Delivery of Buspirone Hydrochloride.Current pharmaceutical biotechnology · 2024Article
- From Poly(glycerol itaconate) Gels to Novel Nonwoven Materials for Biomedical Applications.Gels (Basel, Switzerland) · 2023Article
- Holistic Approach to Process Design and Scale-Up for Itaconic Acid Production from Crude Substrates.Bioengineering (Basel, Switzerland) · 2023Article
- Gamma Radiation-Induced Advanced 2,3-Dimethylacrylic Acid-(2-Acrylamido-2-methyl-1-propanesulfonic Acid) Superabsorbent Hydrogel: Synthesis and Characterization.Gels (Basel, Switzerland) · 2023Article
- Fluorene intercalated graphene oxide based CoQ10 imprinted polymer composite as a selective platform for electrochemical sensing of CoQ10.RSC advances · 2022Article
- Recent Development of Atmospheric Water Harvesting Materials: A Review.ACS materials Au · 2022Review
- Formulation, Characterization, and In Vitro Drug Release Study of β-Cyclodextrin-Based Smart Hydrogels.Gels (Basel, Switzerland) · 2022Article
- Polymer Networks for Enrichment of Calcium Ions.Polymers · 2021Article
- Article
- Polysaccharides-Based Complex Particles' Protective Role on the Stability and Bioactivity of Immobilized Curcumin.International journal of molecular sciences · 2021Article
- An Ustilago maydis chassis for itaconic acid production without by-products.Microbial biotechnology · 2020Article
- Migration of endothelial cells into photo-responsive hydrogels with tunable modulus under the presence of pro-inflammatory macrophages.Regenerative biomaterials · 2019Article
- Oral Drug Delivery Technologies-A Decade of Developments.The Journal of pharmacology and experimental therapeutics · 2019Review
- Review of Stimuli-Responsive Polymers in Drug Delivery and Textile Application.Molecules (Basel, Switzerland) · 2019Review
- Integrated strain- and process design enable production of 220 g LBiotechnology for biofuels · 2019Article
- pH-Responsive carriers for oral drug delivery: challenges and opportunities of current platforms.Drug delivery · 2017Review
- A Stimuli-Responsive, Binary Reagent System for Rapid Isolation of Protein Biomarkers.Analytical chemistry · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Effective oral delivery of proteins is impeded by steep pH gradients and proteolytic enzymes in the gastrointestinal tract, as well as low absorption of the proteins into the bloodstream because of their size, charge, or solubility. In this work, pH-responsive complexation hydrogels of poly(itaconic acid) (PIA) with poly(ethylene glycol) (PEG) grafts were synthesized for applications in oral drug delivery. These hydrogels were expected to be in collapsed configuration at low pH because of hydrogen bonding between PIA carboxyl groups and PEG, and to swell with increasing pH because of charge repulsion between deprotonated carboxylic acid groups. Hydrogels were prepared by UV-initiated free radical polymerization using tetraethylene glycol as the crosslinking agent and Irgacure 2959 as the initiator. The effect of monomer ratios, crosslinking ratio, and solvent amount on the properties of the hydrogels were investigated. The composition of the hydrogels was confirmed by Fourier transform infrared spectroscopy. Equilibrium swelling studies in the pH range of 1.2-7 revealed that the extent of swelling increased with increasing pH up to a pH of about 6, when no further carboxylic acid deprotonation occurred. Studies in Caco-2 colorectal carcinoma cells confirmed the cytocompatibility of these materials at concentrations of up to 5 mg/mL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.