ArticleJournal of artificial organs : the official journal of the Japanese Society for Artificial Organs2009
Beating behavior of primary neonatal cardiomyocytes and cardiac-differentiated P19.CL6 cells on different extracellular matrix components.
Article in Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 23 citations in OpenAlex.
- Magnetic exposure using Samarium Cobalt (SmCScientific reports · 2022Article
- Cardiomyocyte Contractility and Autophagy in a Premature Senescence Model of Cardiac Aging.Oxidative medicine and cellular longevity · 2020Article
- Differential responses of induced pluripotent stem cell-derived cardiomyocytes to anisotropic strain depends on disease status.Journal of biomechanics · 2015Article
- Strategies for the chemical and biological functionalization of scaffolds for cardiac tissue engineering: a review.Journal of the Royal Society, Interface · 2015Review
- Increasing Thermal Stability of Gelatin by UV-Induced Cross-Linking with Glucose.International journal of biomaterials · 2014Article
- Journal of Artificial Organs 2009: the year in review.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2010Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stem cell-based therapy in cardiac tissue engineering is an emerging field that shows great potential for treating heart diseases. However, even preliminary issues, such as the ideal niche for cardiomyocytes, have not been clarified yet. In the present study, the effects of extracellular matrix (ECM) components on the beating duration of neonatal rat cardiomyocytes (RCMs) and on the cardiac differentiation of P19.CL6 carcinoma stem cells were studied. RCMs were cultured on gelatin-, fibronectin-, and collagen type I-coated dishes and on noncoated polystyrene dishes, and their beating rate, beating duration, and cardiac gene expression were evaluated. The beating period and the expression of troponin T type-2 (TNNT2) and troponin C type-1 (TNNC1) of cardiomyocytes cultured on gelatin-coated dishes were longer and higher than for those on dishes with other coatings. For the cardiac differentiation of P19.CL6 cells, troponin T type-2 expression on gelatin- and fibronectin-coated dishes was five times that on collagen type I-coated dishes or polystyrene dishes 11 days after induction. These results indicate that a gelatin-coated surface has a high ability not only to maintain the cardiac phenotype but also to enhance cardiac differentiation.
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