ArticleRadiation and environmental biophysics2009
A new view of radiation-induced cancer: integrating short- and long-term processes. Part I: approach.
Article in Radiation and environmental biophysics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed.
- Machine learning for early prediction of secondary cancer after radiotherapy.Scientific reports · 2025Article
- Utilizing patient data: A tutorial on predicting second cancer with machine learning models.Cancer medicine · 2024Article
- Minimum latency effects for cancer associated with exposures to radiation or other carcinogens.British journal of cancer · 2024Article
- Calculation of Organ Dose Distribution (in-field and Out-of-field) in Breast Cancer Radiotherapy on RANDO Phantom Using GEANT4 Application for Tomographic Emission (Gate) Monte Carlo Simulation.Journal of medical signals and sensors · 2024Article
- Novel Implications of Nanoparticle-Enhanced Radiotherapy and Brachytherapy: Z-Effect and Tumor Hypoxia.Metabolites · 2022Review
- Tumour volume distribution can yield information on tumour growth and tumour control.Zeitschrift fur medizinische Physik · 2022Article
- Pediatric craniospinal irradiation with a short partial-arc VMAT technique for medulloblastoma tumors in dosimetric comparison.Radiation oncology (London, England) · 2020Article
- Estimation of secondary cancer risk after radiotherapy in high-risk prostate cancer patients with pelvic irradiation.Journal of applied clinical medical physics · 2020Article
- Predicting Organ-Specific Risk Interactions between Radiation and Chemotherapy in Secondary Cancer Survivors.Cancers · 2017Article
- Open-Source Radiation Exposure Extraction Engine (RE3) with Patient-Specific Outlier Detection.Journal of digital imaging · 2016Article
- Comparative Risk Predictions of Second Cancers After Carbon-Ion Therapy Versus Proton Therapy.International journal of radiation oncology, biology, physics · 2016Article
- Risk-optimized proton therapy to minimize radiogenic second cancers.Physics in medicine and biology · 2015Article
- Visualization of risk of radiogenic second cancer in the organs and tissues of the human body.Radiation oncology (London, England) · 2015Article
- Modeling age-dependent radiation-induced second cancer risks and estimation of mutation rate: an evolutionary approach.Radiation and environmental biophysics · 2015Article
- Assessment of uncertainties in radiation-induced cancer risk predictions at clinically relevant doses.Medical physics · 2015Article
- Minimizing second cancer risk following radiotherapy: current perspectives.Cancer management and research · 2015Review
- A comparative study on the risks of radiogenic second cancers and cardiac mortality in a set of pediatric medulloblastoma patients treated with photon or proton craniospinal irradiation.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2014Article
- Repopulation of interacting tumor cells during fractionated radiotherapy: stochastic modeling of the tumor control probability.Medical physics · 2013Article
- Second primary cancers after radiation for prostate cancer: a review of data from planning studies.Radiation oncology (London, England) · 2013Review
- Hodgkin's lymphoma emerging radiation treatment techniques: trade-offs between late radio-induced toxicities and secondary malignant neoplasms.Radiation oncology (London, England) · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
Mathematical models of radiation carcinogenesis are important for understanding mechanisms and for interpreting or extrapolating risk. There are two classes of such models: (1) long-term formalisms that track pre-malignant cell numbers throughout an entire lifetime but treat initial radiation dose-response simplistically and (2) short-term formalisms that provide a detailed initial dose-response even for complicated radiation protocols, but address its modulation during the subsequent cancer latency period only indirectly. We argue that integrating short- and long-term models is needed. As an example of this novel approach, we integrate a stochastic short-term initiation/inactivation/repopulation model with a deterministic two-stage long-term model. Within this new formalism, the following assumptions are implemented: radiation initiates, promotes, or kills pre-malignant cells; a pre-malignant cell generates a clone, which, if it survives, quickly reaches a size limitation; the clone subsequently grows more slowly and can eventually generate a malignant cell; the carcinogenic potential of pre-malignant cells decreases with age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.