ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2009
Recombinant human growth hormone improves survival and protects against acute lung injury in murine Staphylococcus aureus sepsis.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Article
- Case Report: Resolution of radiation pneumonitis with androgens and growth hormone.Frontiers in oncology · 2022Article
- Interplay Between the Immune and Endocrine Systems in the Lung: Implications for TB Susceptibility.Frontiers in immunology · 2022Review
- Review
- Sepsis: mechanisms of bacterial injury to the patient.Scandinavian journal of trauma, resuscitation and emergency medicine · 2019Review
- Growth Hormone (GH) and Cardiovascular System.International journal of molecular sciences · 2018Review
- Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced Arthritis.Frontiers in immunology · 2018Article
- Sepsis induced by Staphylococcus aureus: participation of biomarkers in a murine model.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Myeloperoxidase deficiency in mice exacerbates lung inflammation induced by nonviable Candida albicans.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2013Article
- Stevioside protects LPS-induced acute lung injury in mice.Inflammation · 2013Article
- ATF3 Protects against LPS-Induced Inflammation in Mice via Inhibiting HMGB1 Expression.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Links between growth hormone and aging.Endokrynologia Polska · 2013Review
- GH and IGF1: roles in energy metabolism of long-living GH mutant mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Review
- Oroxylin-A rescues LPS-induced acute lung injury via regulation of NF-κB signaling pathway in rodents.PloS one · 2012Article
- Growth hormone, inflammation and aging.Pathobiology of aging & age related diseases · 2012Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate whether recombinant human growth hormone (rhGH) reduces mortality and protects against Staphylococcus aureus sepsis-induced acute lung injury.
methodsThe bacteria-positive rate of blood smears and bacteria colony counts in bacteria plate culture, TNFalpha and IL-10 plasma levels, lung injury score, expression of intercellular adhesion molecule-1 (ICAM-1) as well as activation of nuclear factor-kappa B (NF-kappaB) in the lungs were determined 6, 12 and 24 h after 140 KM mice were injected with physiologic saline (i.p. group C, n = 20); S. aureus E311122 (1.75 x 10(12) cfu/L, 40 ml/kg, i.p. group S, n = 60); or S. aureus (as group S) with a subsequent treatment of rhGH (1.0 U kg(-1) day(-1)), i.m. group T, n = 60). The cumulative survival rate of an additional 15 mice from each group was followed for 7 days post S. aureus injection.
resultsrhGH treatment significantly increased IL-10 plasma levels and the 7-day cumulative survival rate, whereas the bacteria-positive rate of blood smears, bacteria colony counts in bacteria plate cultures, lung injury score, ICAM-1 and NF-kappaB expression in the lungs were significantly reduced. In addition, rhGH treatment significantly suppressed the S. aureus sepsis-induced elevation of TNFalpha plasma levels.
conclusionsThese results indicate an ability of rhGH to prevent S. aureus sepsis-induced acute lung injury in mice, which may be attributed to attenuation of increased plasma TNFalpha levels, and elevated IL-10 plasma levels as well as reduced ICAM-1 expression and inhibited NF-kappaB activity in the lungs.
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