Trial reportOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2010
Resistive vibration exercise attenuates bone and muscle atrophy in 56 days of bed rest: biochemical markers of bone metabolism.
Trial report in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Introducing the Concept of Exercise Holidays for Human Spaceflight - What Can We Learn From the Recovery of Bed Rest Passive Control Groups.Frontiers in physiology · 2022Pooled it
- Effect of artificial gravity on calcaneal bone marrow adipose tissue and mineral content in female and male participants in 60 days of bed rest.Experimental physiology · 2026Trial
- Artificial gravity protects bone and prevents bone marrow adipose tissue accumulation in humans during 60 d of bed rest.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025Trial
- Effect of vibration on orthodontic tooth movement in a double blind prospective randomized controlled trial.Scientific reports · 2022Trial
- Exercise Training Mitigates Multisystem Deconditioning during Bed Rest.Medicine and science in sports and exercise · 2018Trial
- Serum sclerostin and DKK1 in relation to exercise against bone loss in experimental bed rest.Journal of bone and mineral metabolism · 2016Trial
- Trial
- Resistive vibration exercise retards bone loss in weight-bearing skeletons during 60 days bed rest.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Trial
- The effects of bed-rest and countermeasure exercise on the endocrine system in male adults: evidence for immobilization-induced reduction in sex hormone-binding globulin levels.Journal of endocrinological investigation · 2012Trial
- Acute bone marker responses to whole-body vibration and resistance exercise in young women.Journal of clinical densitometry : the official journal of the International Society for Clinical DensitometryTrial
- Development of and adherence to artificial gravity and resistive vibration exercises during 60 days of hypoxic 6° head-down tilt bed rest: BRAVE study.Experimental physiology · 2026Article
- Effects of 14 days of head-down bed rest with or without exercise, and subsequent recovery on bone turnover, density and structure in older adults.Experimental physiology · 2026Article
- Adjuvant pharmacological strategies for the musculoskeletal system during long-term space missions.British journal of clinical pharmacology · 2026Review
- Whole-body vibration transmission during resistance vibration exercise.Frontiers in sports and active living · 2025Article
- Effects of whole-body vibration or resistive-vibration exercise on blood clotting and related biomarkers: a systematic review.NPJ microgravity · 2023Review
- Musculoskeletal research in human space flight - unmet needs for the success of crewed deep space exploration.NPJ microgravity · 2023Review
- The time course of disuse muscle atrophy of the lower limb in health and disease.Journal of cachexia, sarcopenia and muscle · 2022Review
- Dissociation of Bone Resorption and Formation in Spaceflight and Simulated Microgravity: Potential Role of Myokines and Osteokines?Biomedicines · 2022Review
- Early lean mass sparing effect of high-protein diet with excess leucine during long-term bed rest in women.Frontiers in nutrition · 2022Article
- B-Cell Homeostasis Is Maintained During Two Months of Head-Down Tilt Bed Rest With or Without Antioxidant Supplementation.Frontiers in immunology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledDuring and after prolonged bed rest, changes in bone metabolic markers occur within 3 days. Resistive vibration exercise during bed rest impedes bone loss and restricts increases in bone resorption markers whilst increasing bone formation.
introductionTo investigate the effectiveness of a resistive vibration exercise (RVE) countermeasure during prolonged bed rest using serum markers of bone metabolism and whole-body dual X-ray absorptiometry (DXA) as endpoints.
methodsTwenty healthy male subjects underwent 8 weeks of bed rest with 12 months follow-up. Ten subjects performed RVE. Blood drawings and DXA measures were conducted regularly during and after bed rest.
resultsBone resorption increased in the CTRL group with a less severe increase in the RVE group (p = 0.0004). Bone formation markers increased in the RVE group but decreased marginally in the CTRL group (p < 0.0001). At the end of bed rest, the CTRL group showed significant loss in leg bone mass (-1.8(0.9)%, p = 0.042) whereas the RVE group did not (-0.7(0.8)%, p = 0.405) although the difference between the groups was not significant (p = 0.12).
conclusionsThe results suggest the countermeasure restricts increases in bone resorption, increased bone formation, and reduced bone loss during bed rest.
Indexed as
Identifiers
19536451What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.