ArticleJournal of molecular evolution2009
Evolutionary dynamics of recently duplicated genes: Selective constraints on diverging paralogs in the Drosophila pseudoobscura genome.
Article in Journal of molecular evolution, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Adaptive Selection in the Evolution of Aquaglyceroporins in Mammals.Journal of molecular evolution · 2023Article
- Multiple gene movements into and out of haploid sex chromosomes.Genome biology · 2017Article
- Early evolutionary history and genomic features of gene duplicates in the human genome.BMC genomics · 2015Article
- To the beat of a different drum: determinants implicated in the asymmetric sequence divergence of Caenorhabditis elegans paralogs.BMC evolutionary biology · 2013Article
- In with the old, in with the new: the promiscuity of the duplication process engenders diverse pathways for novel gene creation.International journal of evolutionary biology · 2012Article
- Genome-wide analysis of retrogene polymorphisms in Drosophila melanogaster.Genome research · 2011Article
- Annelid Distal-less/Dlx duplications reveal varied post-duplication fates.BMC evolutionary biology · 2011Article
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- Adaptive evolution of genes duplicated from the Drosophila pseudoobscura neo-X chromosome.Molecular biology and evolution · 2010Article
- Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans.Genome research · 2009Article
- A complex suite of forces drives gene traffic from Drosophila X chromosomes.Genome biology and evolution · 2009Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Duplicated genes produce genetic variation that can influence the evolution of genomes and phenotypes. In most cases, for a duplicated gene to contribute to evolutionary novelty it must survive the early stages of divergence from its paralog without becoming a pseudogene. I examined the evolutionary dynamics of recently duplicated genes in the Drosophila pseudoobscura genome to understand the factors affecting these early stages of evolution. Paralogs located in closer proximity have higher sequence identity. This suggests that gene conversion occurs more often between duplications in close proximity or that there is more genetic independence between distant paralogs. Partially duplicated genes have a higher likelihood of pseudogenization than completely duplicated genes, but no single factor significantly contributes to the selective constraints on a completely duplicated gene. However, DNA-based duplications and duplications within chromosome arms tend to produce longer duplication tracts than retroposed and inter-arm duplications, and longer duplication tracts are more likely to contain a completely duplicated gene. Therefore, the relative position of paralogs and the mechanism of duplication indirectly affect whether a duplicated gene is retained or pseudogenized.
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