ArticlePloS one2009
A functional gammadeltaTCR/CD3 complex distinct from gammadeltaT cells is expressed by human eosinophils.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- High-throughput assay confirmation of a T-cell receptor pre-mRNA fragment as a blood-based inflammatory breast cancer biomarker.medRxiv : the preprint server for health sciences · 2025Article
- Blood Eosinophils Are Associated with Efficacy of Targeted Therapy in Patients with Advanced Melanoma.Cancers · 2022Article
- JEV Infection Induces M-MDSC Differentiation Into CD3Frontiers in immunology · 2022Article
- Trilineage Sequencing Reveals Complex TCRβ Transcriptomes in Neutrophils and Monocytes Alongside T Cells.Genomics, proteomics & bioinformatics · 2021Article
- Granulocytes and Cells of Granulocyte Origin-The Relevant Players in Colorectal Cancer.International journal of molecular sciences · 2021Review
- DisruptingMicroorganisms · 2020Article
- T Cell Reprogramming Against Cancer.Methods in molecular biology (Clifton, N.J.) · 2020Review
- Tumor Lipids of Pediatric Papillary Renal Cell Carcinoma Stimulate Unconventional T Cells.Frontiers in immunology · 2020Article
- Circulating monocytes and tumor-associated macrophages express recombined immunoglobulins in glioblastoma patients.Clinical and translational medicine · 2019Article
- Immediate Neutrophil-Variable-T Cell Receptor Host Response in Bacterial Meningitis.Frontiers in neurology · 2019Article
- Expression of combinatorial immunoglobulins in macrophages in the tumor microenvironment.PloS one · 2018Article
- TCRβ-expressing macrophages induced by a pathogenic murine malaria correlate with parasite burden and enhanced phagocytic activity.PloS one · 2018Article
- Review
- Much More than M1 and M2 Macrophages, There are also CD169(+) and TCR(+) Macrophages.Frontiers in immunology · 2015Review
- Extralymphocytic flexible immune recognition: a new angle on inflammation and aging.Aging and disease · 2012Article
- Involvement of eosinophils in the anti-tumor response.Cancer immunology, immunotherapy : CII · 2012Review
- A TNF-regulated recombinatorial macrophage immune receptor implicated in granuloma formation in tuberculosis.PLoS pathogens · 2011Article
- Expression of the T cell receptor αβ on a CD123+ BDCA2+ HLA-DR+ subpopulation in head and neck squamous cell carcinoma.PloS one · 2011Article
- Eosinophils: offenders or general bystanders in allergic airway disease and pulmonary immunity?Journal of innate immunity · 2011Review
- Eosinophils in innate immunity: an evolving story.Cell and tissue research · 2011Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEosinophils are effector cells during parasitic infections and allergic responses. However, their contribution to innate immunity has been only recently unravelled. METHODOLOGY/PRINCIPAL
findingsHere we show that human eosinophils express CD3 and gammadelta T Cell Receptor (TCR) but not alphabeta TCR. Surface expression of gammadeltaTCR/CD3 is heterogeneous between eosinophil donors and inducible by mycobacterial ligands. Surface immunoprecipitation revealed expression of the full gammadeltaTCR/CD3 complex. Real-time PCR amplification for CD3, gamma and delta TCR constant regions transcripts showed a significantly lower expression in eosinophils than in gammadeltaT cells. Limited TCR rearrangements occur in eosinophils as shown by spectratyping analysis of CDR3 length profiles and in situ hybridization. Release by eosinophils of Reactive Oxygen Species, granule proteins, Eosinophil Peroxidase and Eosinophil-Derived Neurotoxin and cytokines (IFN-gamma and TNF-alpha) was observed following activation by gammadeltaTCR-specific agonists or by mycobacteria. These effects were inhibited by anti-gammadeltaTCR blocking antibodies and antagonists. Moreover, gammadeltaTCR/CD3 was involved in eosinophil cytotoxicity against tumor cells. CONCLUSIONS/SIGNIFICANCE: Our results provide evidence that human eosinophils express a functional gammadeltaTCR/CD3 with similar, but not identical, characteristics to gammadeltaTCR from gammadeltaT cells. We propose that this receptor contributes to eosinophil innate responses against mycobacteria and tumors and may represent an additional link between lymphoid and myeloid lineages.
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