ArticleMolecular systems biology2009
Translational switch for long-term maintenance of synaptic plasticity.
Article in Molecular systems biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed.
- Long-term dynamic profiles of cognitive kinases induced by different learning protocols.bioRxiv : the preprint server for biology · 2025Article
- Maintenance of memory by negative-feedback of synaptic protein elimination: Modeling KIBRA-bioRxiv : the preprint server for biology · 2025Article
- Network motifs exhibiting a differential response to spaced and massed inputs.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- RNA epitranscriptomics dysregulation: A major determinant for significantly increased risk of ASD pathogenesis.Frontiers in neuroscience · 2023Article
- Multiscale modeling in the framework of biological systems and its potential for spaceflight biology studies.iScience · 2022Review
- The mTORC1 inhibitor rapamycin and the mTORC1/2 inhibitor AZD2014 impair the consolidation and persistence of contextual fear memory.Psychopharmacology · 2020Article
- Comparing Theories for the Maintenance of Late LTP and Long-Term Memory: Computational Analysis of the Roles of Kinase Feedback Pathways and Synaptic Reactivation.Frontiers in computational neuroscience · 2020Article
- How can memories last for days, years, or a lifetime? Proposed mechanisms for maintaining synaptic potentiation and memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Review
- A continuous model of physiological prion aggregation suggests a role for Orb2 in gating long-term synaptic information.Royal Society open science · 2018Article
- Article
- Computational principles of memory.Nature neuroscience · 2016Review
- Atypical PKCs in memory maintenance: the roles of feedback and redundancy.Learning & memory (Cold Spring Harbor, N.Y.) · 2015Article
- Memory maintenance in synapses with calcium-based plasticity in the presence of background activity.PLoS computational biology · 2014Article
- Dendritic protein synthesis in the normal and diseased brain.Neuroscience · 2013Review
- A mathematical model for astrocytes mediated LTP at single hippocampal synapses.Journal of computational neuroscience · 2012Article
- Translational control by changes in poly(A) tail length: recycling mRNAs.Nature structural & molecular biology · 2012Review
- Regulation of cytoplasmic polyadenylation can generate a bistable switch.BMC systems biology · 2012Article
- Mathematical modeling of sustainable synaptogenesis by repetitive stimuli suggests signaling mechanisms in vivo.PloS one · 2012Article
- Memory-enhancing intra-basolateral amygdala infusions of clenbuterol increase Arc and CaMKIIα protein expression in the rostral anterior cingulate cortex.Frontiers in behavioral neuroscience · 2012Article
- Global analysis of dynamical decision-making models through local computation around the hidden saddle.PloS one · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Memory can last a lifetime, yet synaptic contacts that contribute to the storage of memory are composed of proteins that have much shorter lifetimes. A physiological model of memory formation, long-term potentiation (LTP), has a late protein-synthesis-dependent phase (L-LTP) that can last for many hours in slices or even for days in vivo. Could the activity-dependent synthesis of new proteins account for the persistence of L-LTP and memory? Here, we examine the proposal that a self-sustaining regulation of translation can form a bistable switch that can persistently regulate the on-site synthesis of plasticity-related proteins. We show that an alpha CaMKII-CPEB1 molecular pair can operate as a bistable switch. Our results imply that L-LTP should produce an increase in the total amount of alpha CaMKII at potentiated synapses. This study also proposes an explanation for why the application of protein synthesis and alphaCaMKII inhibitors at the induction and maintenance phases of L-LTP result in very different outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.