ArticleGenes and immunity2009
The evolution and diversity of TNF block haplotypes in European, Asian and Australian Aboriginal populations.
Article in Genes and immunity, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed.
- The immunogenetic basis of ovarian apoptosis: from TNF-α polymorphisms and signaling pathways to glucocorticoid-mediated rescue.Journal of ovarian research · 2026Review
- Relationship between cytomegalovirus antibody levels and cognitive performance is dependent on age and genetic risk.BMC neurology · 2025Article
- Article
- Polymorphisms in inflammation-related genes and the risk of primary varicose veins in ethnic Russians.Immunologic research · 2018Article
- Genetics of HIV-associated sensory neuropathy and related pain in Africans.Journal of neurovirology · 2017Review
- Role of TNF block genetic variants in HIV-associated sensory neuropathy in black Southern Africans.European journal of human genetics : EJHG · 2015Article
- Tumor necrosis factor-alpha polymorphism at position -238 in preeclampsia.Iranian Red Crescent medical journal · 2014Article
- IL10 and TNF variants and risk of non-Hodgkin lymphoma among three Asian populations.International journal of hematology · 2013Article
- TNF haplotypes in a Southern African population resemble those seen in Caucasians and Asians.Genes and immunity · 2013Article
- Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The region spanning the tumour necrosis factor (TNF) cluster in the human major histocompatibility complex is implicated in susceptibility to immunopathological disease, but ethnic differences and linkage disequilibrium have hampered identification of critical polymorphisms. Here, we investigate Europeans, Asians (Bidayuh, Chinese, Indian, Jehai, Malay, Temuan) and Australian Aborigines to provide a framework for disease-association studies. DNA from 999 unrelated healthy donors was genotyped at 38 loci, primarily in coding and promoter regions over a 60-kb region spanning seven genes near TNF. The PHASE algorithm was used to statistically infer TNF block haplotypes and estimate their frequencies in each population. The TNF block is carried as 31 haplotypes in all populations combined, with <19 in any single population. Only six haplotypes have a unique tag single nucleotide polymorphism (SNP) valid for all populations, but seven haplotypes could be tagged with individual SNPs in selected populations. Four to eight TNF block haplotypes exist across all ethnicities, and hence must pre-date the divergence of these populations from a common ancestor >160,000 years ago. Some haplotypes are unique to isolated populations, but they do not contain unique SNP. Hence, they reflect restricted migration and/or extinction of some families rather than de novo mutation.
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