ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2009
Cessation of blood-to-brain influx of interleukin-15 during development of EAE.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- A genetic variant in IL-15Rα correlates with physical activity among European-American adults.Molecular genetics & genomic medicine · 2018Article
- Neuroimmune Axes of the Blood-Brain Barriers and Blood-Brain Interfaces: Bases for Physiological Regulation, Disease States, and Pharmacological Interventions.Pharmacological reviews · 2018Review
- From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery.Nature reviews. Drug discovery · 2016Review
- Sleep restriction impairs blood-brain barrier function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Leukocyte infiltration into spinal cord of EAE mice is attenuated by removal of endothelial leptin signaling.Brain, behavior, and immunity · 2014Article
- Loss of astrocytic leptin signaling worsens experimental autoimmune encephalomyelitis.Brain, behavior, and immunity · 2013Article
- Saturable leptin transport across the BBB persists in EAE mice.Journal of molecular neuroscience : MN · 2013Article
- Brain interleukin-15 in neuroinflammation and behavior.Neuroscience and biobehavioral reviews · 2013Review
- Neuroinflammation: a common pathway in CNS diseases as mediated at the blood-brain barrier.Neuroimmunomodulation · 2012Review
- Interleukin-15 affects serotonin system and exerts antidepressive effects through IL15Rα receptor.Psychoneuroendocrinology · 2011Article
- The effects of IL2Rgamma knockout on depression and contextual memory.Behavioural brain research · 2010Article
- Essential role of interleukin-15 receptor in normal anxiety behavior.Brain, behavior, and immunity · 2010Article
- Cerebral interleukin-15 shows upregulation and beneficial effects in experimental autoimmune encephalomyelitis.Journal of neuroimmunology · 2010Article
- IL-15 receptor deletion results in circadian changes of locomotor and metabolic activity.Journal of molecular neuroscience : MN · 2010Article
- Interleukin-15 receptor is essential to facilitate GABA transmission and hippocampal-dependent memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Cerebral microvascular IL15 is a novel mediator of TNF action.Journal of neurochemistry · 2009Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Regulatory changes in cytokine permeation across the blood-brain barrier (BBB) may have crucial roles in central nervous system (CNS) autoimmune disease. Accordingly, we examined the interactions of interleukin (IL)-15 with the cerebral vasculature after induction of experimental autoimmune encephalomyelitis (EAE). In contrast to the influx of (125)I-IL15 from blood to the CNS in normal mice and the persistence of IL15 influx in the spinal cord of EAE mice, influx was reduced in the EAE brain. Analyses of disappearance kinetics, FITC (fluorescein isothiocyanate)-albumin space, and delivery of IL15 by in situ perfusion, all indicate that the changes were not caused by BBB disruption but by the rapid availability (high volume of distribution) of IL15 and albumin. Although there was no significant change in the BBB permeation of IL15 in either direction in EAE mice, there was an upregulation of its specific receptor, IL15Ralpha, and an increased in situ production of IL15 mRNA that showed regional variation in both basal and EAE states. Overall, for IL15, its increased cerebral vascular space in the brain was equally as important as its persistent influx across the blood-spinal cord barrier, indicating that it is fully capable of activating the upregulated IL15Ralpha in the brain along with the intrinsic CNS source of IL15 in EAE mice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.