Evidence map›Paper›PMID 19536031›Full record

ArticleMedical care2009

The contribution of longitudinal comorbidity measurements to survival analysis.

C Y Wang, Laura-Mae Baldwin, Barry G Saver, Sharon A Dobie, Pamela K Green, Yong Cai, Carrie N Klabunde

Abstract readValidation Study
In one paragraph

Article in Medical care, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

C Y WangDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave North, Seattle, WA 98109, USA. cywang@fhcrc.org
Laura-Mae Baldwin
Barry G Saver
Sharon A Dobie
Pamela K Green
Yong Cai
Carrie N Klabunde

Funding

Carolina Population CenterR24HD050924 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MORGAN, SAMUEL PHILIP · 2005 to 2014
$10.0M
Use of Biomarkers in Diagnosis, Prognosis, Risk Prediction and Early Detection ofP01CA053996 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI HSU, LI · 1991 to 2015
$9.4M
The NonCancer Care of Elderly Colorectal Cancer PatientsR01CA104935 · NCI · UNIVERSITY OF WASHINGTON · PI BALDWIN, LAURA-MAE · 2004 to 2006
$1.3M
NCI NIH HHS 1 R01 CA104935NCI NIH HHS CA53996NCI NIH HHS P01 CA053996NCI NIH HHS R01 CA104935NICHD NIH HHS R24 HD050924
6 · The paper itself

Abstract

backgroundMany clinical and health services research studies are longitudinal, raising questions about how best to use an individual's comorbidity measurements over time to predict survival.

objectivesTo evaluate the performance of different approaches to longitudinal comorbidity measurement in predicting survival, and to examine strategies for addressing the inevitable issue of missing data. RESEARCH

designRetrospective cohort study using Cox regression analysis to examine the association between various Romano-Charlson comorbidity measures and survival. SUBJECTS: Fifty thousand cancer-free individuals aged 66 or older enrolled in Medicare between 1991 and 1999 for at least 1 year.

resultsThe best fitting model combined both time independent baseline comorbidity and the time dependent prior year comorbidity measure. The worst fitting model included baseline comorbidity only. Overall, the models fit best when using the "rolling" comorbidity measures that assumed chronic conditions persisted rather than measures using only prior year's recorded diagnoses.

conclusionsLongitudinal comorbidity is an important predictor of survival, and investigators should make use of individuals' longitudinal comorbidity data in their regression modeling.

Indexed as

ComorbidityLongitudinal StudiesProportional Hazards ModelsSurvival AnalysisAgedCause of DeathData CollectionData Interpretation, StatisticalFemaleGeriatric AssessmentHealth Services ResearchHealth StatusHealth Status IndicatorsHumansLikelihood FunctionsMale

Identifiers

PMID19536031
PMCPMC2701975

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.