ArticleJournal of neuropathology and experimental neurology2009
Neurotrophic factors improve motoneuron survival and function of muscle reinnervated by embryonic neurons.
Article in Journal of neuropathology and experimental neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 53 citations in OpenAlex.
- Toward an Integrated Strategy for Volumetric Muscle Loss Regeneration.Journal of clinical medicine · 2026Review
- Combined Neuroprotective Effects of N,N-Dimethyltryptamine and Ventral Root Reimplantation Following Spinal Root Avulsion in Rats.Journal of neurochemistry · 2026Article
- Functional Reconstruction of Denervated Muscle by Xenotransplantation of Neural Cells from Porcine to Rat.International journal of molecular sciences · 2022Article
- A Therapeutic Strategy for Lower Motor Neuron Disease and Injury Integrating Neural Stem Cell Transplantation and Functional Electrical Stimulation in a Rat Model.International journal of molecular sciences · 2022Article
- The Bridging Effect of Controlled-Release Glial Cell-Derived Neurotrophic Factor Microcapsules within Nerve Conduits on Rat Facial Nerve Regeneration.Disease markers · 2022Article
- Electrical stimulation of human neural stem cells via conductive polymer nerve guides enhances peripheral nerve recovery.Biomaterials · 2021Article
- Transplanting Cells for Spinal Cord Repair: Who, What, When, Where and Why?Cell transplantation · 2019Article
- Peripheral Nerve Nanoimaging: Monitoring Treatment and Regeneration.The AAPS journal · 2017Review
- Reinnervation of denervated muscle by implantation of nerve-muscle-endplate band graft to the native motor zone of the target muscle.Brain and behavior · 2017Article
- Alpinia oxyphylla Miq. fruit extract activates IGFR-PI3K/Akt signaling to induce Schwann cell proliferation and sciatic nerve regeneration.BMC complementary and alternative medicine · 2017Article
- Tumor prevention facilitates delayed transplant of stem cell-derived motoneurons.Annals of clinical and translational neurology · 2016Article
- Muscle reinnervation with nerve-muscle-endplate band grafting technique: correlation between force recovery and axonal regeneration.The Journal of surgical research · 2015Article
- Successful transplantation of motoneurons into the peripheral nerve depends on the number of transplanted cells.Nagoya journal of medical science · 2015Article
- Motoneurons derived from induced pluripotent stem cells develop mature phenotypes typical of endogenous spinal motoneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Restorative effect and mechanism of mecobalamin on sciatic nerve crush injury in mice.Neural regeneration research · 2014Article
- Electrical stimulation of transplanted motoneurons improves motor unit formation.Journal of neurophysiology · 2014Article
- Promotion of survival and differentiation of neural stem cells with fibrin and growth factor cocktails after severe spinal cord injury.Journal of visualized experiments : JoVE · 2014Article
- Partial restoration of cardiovascular function by embryonic neural stem cell grafts after complete spinal cord transection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Transplantated mesenchymal stem cells derived from embryonic stem cells promote muscle regeneration and accelerate functional recovery of injured skeletal muscle.BioResearch open access · 2013Article
- Electrical stimulation of embryonic neurons for 1 hour improves axon regeneration and the number of reinnervated muscles that function.Journal of neuropathology and experimental neurology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Motoneuron death can occur over several spinal levels with disease or trauma, resulting in muscle denervation. We tested whether cotransplantation of embryonic neurons with 1 or more neurotrophic factors into peripheral nerve improved axon regeneration, muscle fiber area, reinnervation, and function to a greater degree than cell transplantation alone. Sciatic nerves of adult Fischer rats were cut to denervate muscles; 1 week later, embryonic ventral spinal cord cells (days 14-15) were transplanted into the tibial nerve stump as the only source of neurons for muscle reinnervation. Factors that promote motoneuron survival (cardiotrophin 1; fibroblast growth factor 2; glial cell line-derived neurotrophic factor; insulin-like growth factor 1; leukemia inhibitory factor; and hepatocyte growth factor) were added to the transplant individually or in combinations. Inclusion of a single factor with the cells resulted in comparable myelinated axon counts, muscle fiber areas, and evoked electromyographic activity to cells alone 10 weeks after transplantation. Only cell transplantation with glial cell line-derived neurotrophic factor, hepatocyte growth factor, and insulin-like growth factor 1 significantly increased motoneuron survival, myelinated axon counts, muscle reinnervation, and evoked electromyographic activity compared with cells alone. Thus, immediate application of a specific combination of factors to dissociated embryonic neurons improves survival of motoneurons and the long-term function of reinnervated muscle.
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