ArticleJournal of immunology (Baltimore, Md. : 1950)2009
Fusion loop peptide of the West Nile virus envelope protein is essential for pathogenesis and is recognized by a therapeutic cross-reactive human monoclonal antibody.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- Epitope(s) involving amino acids of the fusion loop of Japanese encephalitis virus envelope protein is(are) important to elicit protective immunity.Journal of virology · 2024Article
- A combination of two resistance mechanisms is critical for tick-borne encephalitis virus escape from a broadly neutralizing human antibody.Cell reports · 2023Article
- Isolation of Exosomes or Extracellular Vesicles from West Nile Virus-Infected N2a Cells, Primary Cortical Neurons, and Brain Tissues.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Dynamics of the Magnitude, Breadth and Depth of the Antibody Response at Epitope Level Following Dengue Infection.Frontiers in immunology · 2021Article
- Discovery of Exosomes From Tick Saliva and Salivary Glands Reveals Therapeutic Roles for CXCL12 and IL-8 in Wound Healing at the Tick-Human Skin Interface.Frontiers in cell and developmental biology · 2020Article
- Exosomes mediate Zika virus transmission through SMPD3 neutral Sphingomyelinase in cortical neurons.Emerging microbes & infections · 2019Article
- Arthropod EVs mediate dengue virus transmission through interaction with a tetraspanin domain containing glycoprotein Tsp29Fb.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Exosomes serve as novel modes of tick-borne flavivirus transmission from arthropod to human cells and facilitates dissemination of viral RNA and proteins to the vertebrate neuronal cells.PLoS pathogens · 2018Article
- Insight into SNPs and epitopes of E protein of newly emerged genotype-I isolates of JEV from Midnapur, West Bengal, India.BMC immunology · 2017Article
- Antibody Prophylaxis Against Dengue Virus 2 Infection in Non-Human Primates.The American journal of tropical medicine and hygiene · 2016Article
- Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- An Overview of Current Approaches Toward the Treatment and Prevention of West Nile Virus Infection.Methods in molecular biology (Clifton, N.J.) · 2016Article
- Transmission-Blocking Vaccines: Focus on Anti-Vector Vaccines against Tick-Borne Diseases.Archivum immunologiae et therapiae experimentalis · 2015Review
- Risk factors for West Nile virus infection and disease in populations and individuals.Expert review of anti-infective therapy · 2015Review
- Review
- Envelope protein gene based molecular characterization of Japanese encephalitis virus clinical isolates from West Bengal, India: a comparative approach with respect to SA14-14-2 live attenuated vaccine strain.BMC infectious diseases · 2013Article
- Possible future monoclonal antibody (mAb)-based therapy against arbovirus infections.BioMed research international · 2013Review
- Viral membrane fusion and nucleocapsid delivery into the cytoplasm are distinct events in some flaviviruses.PLoS pathogens · 2013Article
- West Nile Virus: biology, transmission, and human infection.Clinical microbiology reviews · 2012Review
- Semaphorin 7A contributes to West Nile virus pathogenesis through TGF-β1/Smad6 signaling.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
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Authors and funding
15 authors at 7 institutions in 3 countries.
Funding
Abstract
West Nile virus is an emerging pathogen that can cause fatal neurological disease. A recombinant human mAb, mAb11, has been described as a candidate for the prevention and treatment of West Nile disease. Using a yeast surface display epitope mapping assay and neutralization escape mutant, we show that mAb11 recognizes the fusion loop, at the distal end of domain II of the West Nile virus envelope protein. Ab mAb11 cross-reacts with all four dengue viruses and provides protection against dengue (serotypes 2 and 4) viruses. In contrast to the parental West Nile virus, a neutralization escape variant failed to cause lethal encephalitis (at higher infectious doses) or induce the inflammatory responses associated with blood-brain barrier permeability in mice, suggesting an important role for the fusion loop in viral pathogenesis. Our data demonstrate that an intact West Nile virus fusion loop is critical for virulence, and that human mAb11 targeting this region is efficacious against West Nile virus infection. These experiments define the molecular determinant on the envelope protein recognized by mAb11 and demonstrate the importance of this region in causing West Nile encephalitis.
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Registered trials
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