ArticleJournal of immunology (Baltimore, Md. : 1950)2009
T-bet knockout prevents Helicobacter felis-induced gastric cancer.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- T-bet: biological functions, molecular mechanisms, and therapeutic applications: a systematic review.Frontiers in immunology · 2026Pooled it
- Bad bugs mean business: gastric cancer is an intended consequence ofInfection and immunity · 2026Review
- SustainedLife science alliance · 2021Article
- Prevalence of non Helicobacter pylori gastric Helicobacters in Iranian dyspeptic patients.BMC gastroenterology · 2020Article
- Gastric cancer: genome damaged by bugs.Oncogene · 2020Review
- Aim2-mediated/IFN-β-independent regulation of gastric metaplastic lesions via CD8+ T cells.JCI insight · 2020Article
- Curcumin inhibits liver metastasis of gastric cancer through reducing circulating tumor cells.Aging · 2019Article
- Indoleamine 2,3-Dioxygenase 1, Increased in Human Gastric Pre-Neoplasia, Promotes Inflammation and Metaplasia in Mice and Is Associated With Type II Hypersensitivity/Autoimmunity.Gastroenterology · 2018Article
- Review
- Autoimmunity as a double agent in tumor killing and cancer promotion.Frontiers in immunology · 2014Review
- Article
- Life in the human stomach: persistence strategies of the bacterial pathogen Helicobacter pylori.Nature reviews. Microbiology · 2013Review
- Higher numbers of T-bet(+) intratumoral lymphoid cells correlate with better survival in gastric cancer.Cancer immunology, immunotherapy : CII · 2013Article
- Association between gastric cancer and -1993 polymorphism of TBX21 gene.World journal of gastroenterology · 2012Article
- The role of Th cell subsets in the control of Helicobacter infections and in T cell-driven gastric immunopathology.Frontiers in immunology · 2012Article
- Effects of myeloid differentiation primary response gene 88 (MyD88) activation on Helicobacter infection in vivo and induction of a Th17 response.Helicobacter · 2011Article
- Mechanisms of intestinal inflammation and development of associated cancers: lessons learned from mouse models.Mutation researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Helicobacter infection is the primary risk factor for gastric cancer, with the cytokine environment within the gastric mucosa the strongest predictor of disease risk. Elevated TNF-alpha, IL-1beta, and low IL-10 are associated with the highest risk. In this study, we used C57BL/6 mice to identify T-bet as a central regulator of the cytokine environment during Helicobacter felis infection. We infected male and female C57BL/6 and C57BL/6-T-bet knockout (KO) litter mates with H. felis and examined the bacterial colonization, immune response, and mucosal damage at varying time points. T-bet KO mice maintained infection for 15 mo at similar levels to wild-type mice. Infection and immune response did not differ between male and female mice. Despite sustained infection, T-bet KO mice respond with a blunted Th1 response associated with preservation of parietal and chief cells and protection from the development of gastric cancer. Unexpectedly, T-bet KO mice develop a gastric environment that would not be expected based on the phenotype of T-bet KO CD4 cells alone. T-bet KO mice respond to H. felis infection with a markedly blunted IL-1beta and TNF-alpha and elevated IL-10 levels. Activity of this one master regulator modulates the expression of the key gastric mucosal cytokines associated with gastric cancer and may be a target for therapy to restore immune balance clinically in patients at risk for gastric cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.