ArticleSocial cognitive and affective neuroscience2009
Genetic contributions of the serotonin transporter to social learning of fear and economic decision making.
Article in Social cognitive and affective neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it, 165 citations in OpenAlex.
- The Genetics of Risk Aversion: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- Serotoninergic effects on judgments and social learning of trustworthiness.Psychopharmacology · 2014Trial
- Partial Serotonin Transporter Deficiency Modulates Plasma Metabolome, Arginine-Nitric Oxide Pathway and Emotional Behavior in Mice Exposed to Western Diet.Metabolites · 2026Article
- Genetic Inactivation of the Serotonin Transporter Dysregulates Expression of Neurotransmission Genes and Genome-Wide DNA Methylation Levels in the Medial Prefrontal Cortex of Male Rats During Postnatal Development.Developmental neurobiology · 2025Article
- The Role of Serotonin in Fear Learning and Memory: A Systematic Review of Human Studies.Brain sciences · 2023Review
- Dopaminergic challenge dissociates learning from primary versus secondary sources of information.eLife · 2022Article
- Socioemotional Mechanisms of Children's Differential Response to the Effects of Maternal Sensitivity on Child Adjustment.Parenting, science and practice · 2021Article
- Personality and Genetics Correlations to Risk-Taking Using Quantum Decision Theory in Balloon Analogue Risk Tasks.Cureus · 2020Review
- The association between serotonin transporter availability and the neural correlates of fear bradycardia.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Genetic influence alters the brain synchronism in perception and timing.Journal of biomedical science · 2018Review
- Risk-seeking for losses is associated with 5-HTTLPR, but not with transient changes in 5-HT levels.Psychopharmacology · 2018Article
- Neural substrates of context- and person-dependent altruistic punishment.Human brain mapping · 2017Article
- Identifying new susceptibility genes on dopaminergic and serotonergic pathways for the framing effect in decision-making.Social cognitive and affective neuroscience · 2017Article
- Social Fear Learning: from Animal Models to Human Function.Trends in cognitive sciences · 2017Review
- Genetic variation of dopamine and serotonin function modulates the feedback-related negativity during altruistic punishment.Scientific reports · 2017Article
- The neural underpinnings of cognitive flexibility and their disruption in psychotic illness.Neuroscience · 2017Review
- Serotonin Transporter Genetic Variation is Differentially Associated with Reflexive- and Reflective-Optimal Learning.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Understanding Risky Behavior: The Influence of Cognitive, Emotional and Hormonal Factors on Decision-Making under Risk.Frontiers in psychology · 2017Review
- All framing effects are not created equal: Low convergent validity between two classic measurements of framing.Scientific reports · 2016Article
- Variant at serotonin transporter gene predicts increased imitation in toddlers: relevance to the human capacity for cumulative culture.Biology letters · 2016Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serotonin (5-HT) modulates emotional and cognitive functions such as fear conditioning (FC) and decision making. This study investigated the effects of a functional polymorphism in the regulatory region (5-HTTLPR) of the human 5-HT transporter (5-HTT) gene on observational FC, risk taking and susceptibility to framing in decision making under uncertainty, as well as multidimensional anxiety and autonomic control of the heart in healthy volunteers. The present results indicate that in comparison to the homozygotes for the long (l) version of 5-HTTLPR, the carriers of the short (s) version display enhanced observational FC, reduced financial risk taking and increased susceptibility to framing in economic decision making. We also found that s-carriers have increased trait anxiety due to threat in social evaluation, and ambiguous threat perception. In addition, s-carriers also show reduced autonomic control over the heart, and a pattern of reduced vagal tone and increased sympathetic activity in comparison to l-homozygotes. This is the first genetic study that identifies the association of a functional polymorphism in a key neurotransmitter-related gene with complex social-emotional and cognitive processes. The present set of results suggests an endophenotype of anxiety disorders, characterized by enhanced social learning of fear, impaired decision making and dysfunctional autonomic activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.