ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Spontaneous calcium spike activity in embryonic spinal neurons is regulated by developmental expression of the Na+, K+-ATPase beta3 subunit.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Deciphering the Calcium Code: A Review of Calcium Activity Analysis Methods Employed to Identify Meaningful Activity in Early Neural Development.Biomolecules · 2024Review
- Cellular identity and CaScientific reports · 2020Article
- Calcium Activity Dynamics Correlate with Neuronal Phenotype at a Single Cell Level and in a Threshold-Dependent Manner.International journal of molecular sciences · 2019Article
- Spontaneous calcium activity in metanephric mesenchymal cells regulates branching morphogenesis in the embryonic kidney.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Elevated intracellular NaJournal of neurochemistry · 2017Article
- In vivo Calcium Imaging of Evoked Calcium Waves in the Embryonic Cortex.Frontiers in cellular neuroscience · 2015Article
- The role of voltage-gated calcium channels in neurotransmitter phenotype specification: Coexpression and functional analysis in Xenopus laevis.The Journal of comparative neurology · 2014Article
- Article
- Dissection, culture, and analysis of Xenopus laevis embryonic retinal tissue.Journal of visualized experiments : JoVE · 2012Article
- Activity-dependent neurotransmitter respecification.Nature reviews. Neuroscience · 2012Review
- Stem cells and calcium signaling.Advances in experimental medicine and biology · 2012Review
- Calcium signaling in neuronal development.Cold Spring Harbor perspectives in biology · 2011Review
- Physiology of the gonadotrophin-releasing hormone (GnRH) neurone: studies from embryonic GnRH neurones.Journal of neuroendocrinology · 2011Review
- cJun integrates calcium activity and tlx3 expression to regulate neurotransmitter specification.Nature neuroscience · 2010Article
- Target-dependent regulation of neurotransmitter specification and embryonic neuronal calcium spike activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Homer regulates calcium signalling in growth cone turning.Neural development · 2009Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Different types and patterns of spontaneous electrical activity drive many aspects of neuronal differentiation. Neurons in the developing Xenopus spinal cord exhibit calcium spikes, which regulate gene transcription and neurotransmitter specification. The ionic currents necessary for spike production have been described. However, the mechanisms that generate the onset of this activity and the basis of its regulation remain unclear. Although signaling molecules appear to act on plasma membrane receptors to trigger calcium spike activity, other mechanisms for spontaneous calcium spike regulation may exist as well. Here, we analyze the developmental expression of the Na(+), K(+)-ATPase beta3 subunit in Xenopus tropicalis embryos and show that its levels are downregulated at a time during embryonic development that coincides with the onset of prominent calcium spike activity in spinal neurons. Inhibition of an earlier increase in beta3 expression leads to more depolarized resting membrane potentials and results in later reduction of spike activity. This suppression of beta3 levels also reduces expression of the store-operated calcium channel subunit, Orai1. These findings suggest that the Na(+), K(+)-ATPase plays a role in initiating calcium spike activity and regulating calcium homeostasis.
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